|
Central neuroblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We found that stable or transient expression of full-length alpha-Pal/NRF-1 in human neuroblastoma IMR-32 cells significantly induced neurite outgrowth and increased the length of neurites both in medium containing 10% fetal bovine serum and in serum-free medium.
|
15992771 |
2005 |
|
Central neuroblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Overall, our data showed that the combination of genome-wide bioinformatic analysis and biological experiments helps to identify the novel NRF-1-regulated genes, which play roles in differentiation of neuroblastoma cells.
|
23219993 |
2013 |
|
Chagas Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and chagasic patients: the role of Nrf1/2 and antioxidant response.
|
23316324 |
2012 |
|
Childhood Neuroblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We found that stable or transient expression of full-length alpha-Pal/NRF-1 in human neuroblastoma IMR-32 cells significantly induced neurite outgrowth and increased the length of neurites both in medium containing 10% fetal bovine serum and in serum-free medium.
|
15992771 |
2005 |
|
Childhood Neuroblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Overall, we annotated FAM134C, C3orf10, and ENOX1 as NRF-1-regulated genes, which have differential effects on neurite outgrowth in neuroblastoma cells as well as neurons.
|
23939472 |
2013 |
|
Childhood Neuroblastoma
|
0.050 |
PosttranslationalModification
|
disease |
BEFREE |
In the present study, we focused on the epigenetic effects of TBT and investigated whether TBT decreases NRF-1 expression via epigenetic modifications in SH-SY5Y human neuroblastoma cells.
|
29345269 |
2018 |
|
Childhood Neuroblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Notably, there also exists a proteasomal 'bounce-back' response mediated by Nrf1, insofar as to enhance the drug resistance to proteasomal inhibitors in clinical treatment of neuroblastoma, multiple myeloma and triple-negative breast cancers.
|
30267745 |
2018 |
|
Childhood Neuroblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Overall, our data showed that the combination of genome-wide bioinformatic analysis and biological experiments helps to identify the novel NRF-1-regulated genes, which play roles in differentiation of neuroblastoma cells.
|
23219993 |
2013 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that the mitochondrial degeneration engaged in the skeletal muscle atrophy and the heart failure in the NF90 Tg mice may be caused by NF90-induced posttranscriptional repression of transcription factors such as PGC-1 and NRF-1 for regulating nuclear-encoded genes relevant to mitochondrial function.
|
22912857 |
2012 |
|
Corneal Neovascularization
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, our data suggest TMP downregulates CXCR4 by repressing NRF-1 expression in CNV, likely indirectly by downregulating NFκB.
|
29801148 |
2018 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
NRF-1 regulates stress response genes that contain the antioxidant response element (ARE), and HCMV infection is associated with increased expression of many stress response genes when US27 is present.
|
30209167 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
|
12832613 |
2003 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
According to the results, ASIV can regulate energy metabolism by regulating the release of PGC‑1α and NRF1 to rescue the abnormal energy metabolism caused by diabetes mellitus, thus decreasing the myocardial damage caused by diabetic cardiomyopathy.
|
31702040 |
2019 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
|
12832613 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated that the polymorphism in TP53 (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (rs1882095) increased the risk of type 2 diabetes.
|
21146886 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The present study shows an association of SNPs in the NRF1 gene with type 2 diabetes in a Han Chinese population.
|
18071027 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The NRF1 gene was sequenced to identify polymorphisms in 24 Korean DNA samples and then common variants were genotyped in 766 patients with type 2 diabetes and 303 non-diabetic subjects.
|
16082529 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
Biomarker
|
disease |
BEFREE |
Such dual control of the two pathways by NRF-1 place it as critical gene in the design of therapeutic modalities much needed to cure or better manage type 2 diabetes.
|
28263745 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
At baseline, no differences were observed in NRF1-density between the T2DM men and the CON, while the contents of PGC1α and TFAM were decreased in the T2DM men.
|
23210442 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes associations in PPARG, KCNJ11, and SLC2A2; identified significant SNPs in genes with previously reported associations (ENPP1 [rs2021966, P = 0.00026] and NRF1 [rs1882095, P = 0.00096]); and implicated novel genes, including RAPGEF1 (rs4740283, P = 0.00013) and TP53 (rs1042522, Arg72Pro, P = 0.00086), in type 2 diabetes susceptibility.
|
18678618 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that insulin resistance and DM associate with reduced expression of multiple nuclear respiratory factor-1 (NRF-1)-dependent genes encoding key enzymes in oxidative metabolism and mitochondrial function.
|
12832613 |
2003 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrf1 and Nrf2 are relevant in disease presentation and overall survival in high-risk DLBCL.
|
30755497 |
2019 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date.
|
30562963 |
2018 |
|
Encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings suggest that a combination of subunit displacement and reduced Nrf1 expression may be responsible for c-20S impairment in EAE.
|
31709534 |
2020 |
|
Epithelial ovarian cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interindividual variation involving BIO was most strongly associated with EOC risk (empirical P = 0.050), especially for NRF1, MTERF, PPARGC1A, ESRRA, and CAMK2D.
|
21447778 |
2011 |