Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 GeneticVariation disease BEFREE However, they revealed a significant association between the NR4A2 gene haplotype and alcohol dependence, indicating that 2q22-q23 including the NR4A2 gene locus is a possible genomic region contributing to genetic susceptibility to alcohol dependence. 11840500 2002
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.320 AlteredExpression disease BEFREE NURR1 was abundantly expressed in the inflammatory cells of both RA and PsA synovium. 11315917 2001
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.320 AlteredExpression disease BEFREE MTX significantly suppresses expression of NURR1 in vivo in patients with active psoriatic arthritis (n = 10; p < 0.002) who were prescribed low-dose MTX for management of peripheral arthritis. 15972692 2005
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.320 Biomarker disease BEFREE We performed a mutation screen of NR4A2 (also known as NURR1) in 409 Parkinson's disease (PD) patients. 19429166 2009
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.320 AlteredExpression disease BEFREE However, NURR1 (57.631% reduced in males; 28.93% in females) and FOXA1 (64.42% in males; 55.76% in females) mRNA expression did differ greatly between male and female PD patients. 28255498 2017
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker disease BEFREE In the present study, we show that each of these transcription factors is robustly expressed in adult dopamine neurons in human midbrain, and that cocaine abuse is associated with a significant decrease in the abundance of Nurr1 and Pitx3 in these cells. 15094491 2004
CUI: C0023015
Disease: Language Disorders
Language Disorders 		0.310 Biomarker group BEFREE Our findings of a de novo deletion of NR4A2 in an individual with mild intellectual disability and prominent speech and language impairment provides further evidence for NR4A2 haploinsufficiency being causative for neurodevelopmental and particularly language phenotypes. 28544326 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease BEFREE Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls. 16631355 2006
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.310 Biomarker phenotype BEFREE There is a highly homologous NURR1 gene in humans (formerly known as NOT) which therefore constitutes a good candidate gene for neurologic and psychiatric disorders with an involvement of the dopamine neuron system, such as Parkinson's disease, schizophrenia, and manic-depression. 11121187 2000
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.310 Biomarker disease BEFREE Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls. 16631355 2006
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.310 Biomarker group BEFREE NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder. 29770430 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 AlteredExpression disease BEFREE Our findings suggest that activation of Nurr1 might be therapeutically useful in Parkinson's disease. 11113533 2000
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 Biomarker disease BEFREE Neuroprotective effect of olfactory ensheathing cells co-transfected with Nurr1 and Ngn2 in both in vitro and in vivo models of Parkinson's disease. 29291419 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 AlteredExpression disease BEFREE The observed reduction in PBL NURR1 gene expression indicates possible systemic involvement in PD, and the finding may help identify individuals with PD and other disorders associated with impaired central DAergic system. 18684475 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 Biomarker disease BEFREE Taken together, these data suggest that C-DIM12 is an activator of Nurr1 that suppresses glial activation and neuronal loss in vivo after treatment with MPTP, and that this receptor could be an efficacious target for disease modification in individuals with Parkinson's disease and related disorders. 29626009 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 Biomarker disease BEFREE This review highlights the recent progress in preclinical studies of Nurr1-based therapies and discusses the outlook of this emerging therapy as a promising new generation of PD medication. 27012974 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 GeneticVariation disease BEFREE NURR1 alterations have been linked to DA-associated brain disorders, such as Parkinson's disease and schizophrenia. 31455763 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 Biomarker disease BEFREE Bis-indole derivatives including 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane (DIM-C-pPhCl) and substituted quinolines such as chloroquine (CQ) and amodiaquine (AQ) are nuclear receptor 4A2 (NR4A2, Nurr1) ligands, and they exhibit anti-inflammatory activities in mouse and rat models of Parkinson's disease, respectively. 31102570 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 GeneticVariation disease BEFREE NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. 12815740 2003
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 GeneticVariation disease BEFREE These results suggest that the NR4A2 IVS6 +18insG polymorphism may play a minor role in PD susceptibility among Taiwanese women. 17427185 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 AlteredExpression disease BEFREE Our results provide useful information that the NURR1 and PITX3 gene expression is decreased in the PBL of Chinese patients with PD, indicating their possible systemic involvement in PD. 22309633 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 Biomarker disease BEFREE There is a highly homologous NURR1 gene in humans (formerly known as NOT) which therefore constitutes a good candidate gene for neurologic and psychiatric disorders with an involvement of the dopamine neuron system, such as Parkinson's disease, schizophrenia, and manic-depression. 11121187 2000
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 AlteredExpression disease BEFREE Graphical Abstract In the rat rotenone model of Parkinson's disease (PD), Nurr1 expression was downregulated, GSK-3β was activated, and autophagic flux was inhibited. 29429051 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 GeneticVariation disease BEFREE These results indicate that Ser125 is critical for basal and ERK1/2-induced NURR1 activity and suggest a role for this and other NURR1 mutations in the regulation of dopamine synthesis and predisposition to Parkinson's disease. 17890097 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 Biomarker disease BEFREE Altogether, the enhancement of tyrosine hydroxylase in naïve dopaminergic cells and the protective effects in a cellular model of Parkinson's disease suggest that full-length Nurr1 fusion protein may contribute to the development of a novel concept of protein-based therapy. 30121937 2019