Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 Biomarker disease BEFREE Nuclear orphan receptor NR4A2 modulates fatty acid oxidation pathways in colorectal cancer. 21757690 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 Biomarker disease BEFREE Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. 19549529 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder. 16631355 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 AlteredExpression disease BEFREE These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder. 16631355 2006
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 Biomarker disease CTD_human Human colorectal cancers relative to matched normal mucosa showed increased NR4A2 expression. 16293616 2006
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 AlteredExpression disease BEFREE Human colorectal cancers relative to matched normal mucosa showed increased NR4A2 expression. 16293616 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism. 15635645 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G). 15211629 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE NURR1 mutations in cases of schizophrenia and manic-depressive disorder. 11121187 2000
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease PSYGENET Polymorphisms in the regulatory region of Nurr1 are implicated in pathogenesis of alcohol dependence and the Nurr1/dopamine signaling pathway might be important for this dependence development in Mexican Americans. 23066323 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease BEFREE Polymorphisms in the regulatory region of Nurr1 are implicated in pathogenesis of alcohol dependence and the Nurr1/dopamine signaling pathway might be important for this dependence development in Mexican Americans. 23066323 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 GeneticVariation disease BEFREE To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism. 15635645 2005
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease LHGDN However, they revealed a significant association between the NR4A2 gene haplotype and alcohol dependence, indicating that 2q22-q23 including the NR4A2 gene locus is a possible genomic region contributing to genetic susceptibility to alcohol dependence. 11840500 2002
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 GeneticVariation disease BEFREE However, they revealed a significant association between the NR4A2 gene haplotype and alcohol dependence, indicating that 2q22-q23 including the NR4A2 gene locus is a possible genomic region contributing to genetic susceptibility to alcohol dependence. 11840500 2002
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.320 AlteredExpression disease BEFREE However, NURR1 (57.631% reduced in males; 28.93% in females) and FOXA1 (64.42% in males; 55.76% in females) mRNA expression did differ greatly between male and female PD patients. 28255498 2017
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.320 Biomarker disease CTD_human Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. 19732956 2009
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.320 Biomarker disease BEFREE We performed a mutation screen of NR4A2 (also known as NURR1) in 409 Parkinson's disease (PD) patients. 19429166 2009
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.320 AlteredExpression disease BEFREE MTX significantly suppresses expression of NURR1 in vivo in patients with active psoriatic arthritis (n = 10; p < 0.002) who were prescribed low-dose MTX for management of peripheral arthritis. 15972692 2005
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.320 AlteredExpression disease BEFREE NURR1 was abundantly expressed in the inflammatory cells of both RA and PsA synovium. 11315917 2001
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.320 Biomarker disease CTD_human
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.310 Biomarker group BEFREE NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder. 29770430 2018
CUI: C0023015
Disease: Language Disorders
Language Disorders 		0.310 Biomarker group BEFREE Our findings of a de novo deletion of NR4A2 in an individual with mild intellectual disability and prominent speech and language impairment provides further evidence for NR4A2 haploinsufficiency being causative for neurodevelopmental and particularly language phenotypes. 28544326 2017
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.310 Biomarker group CTD_human Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. 16293616 2006
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.310 Biomarker group LHGDN Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. 16293616 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease BEFREE Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls. 16631355 2006