|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
OPCML belongs to the IgLON family of Ig domain-containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.
|
28407749 |
2017 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
OPCML expression was markedly reduced in tumor tissues and cancer cell lines.
|
28407749 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
OPCML expression was markedly reduced in tumor tissues and cancer cell lines.
|
28407749 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Opioid-binding protein/cell adhesion molecule-like (OPCML) is a tumor-suppressor gene that is frequently inactivated in ovarian cancer and many other cancers by somatic methylation.
|
28775148 |
2017 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Opioid-binding protein/cell adhesion molecule-like (OPCML) is a tumor-suppressor gene that is frequently inactivated in ovarian cancer and many other cancers by somatic methylation.
|
28775148 |
2017 |
|
Breast Carcinoma
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Also, we show that high OPCML expression is associated with better response to lapatinib therapy in breast cancer patients and better survival in HER2-overexpressing ovarian cancer patients, suggesting that OPCML co-therapy could be a valuable sensitizing approach to RTK inhibitors.<i></i>.
|
28775148 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, we show that high OPCML expression is associated with better response to lapatinib therapy in breast cancer patients and better survival in HER2-overexpressing ovarian cancer patients, suggesting that OPCML co-therapy could be a valuable sensitizing approach to RTK inhibitors.<i></i>.
|
28775148 |
2017 |
|
Stomach Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.
|
17109515 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Down-regulated OPCML expression might serve as an independent predictor for unfavorable prognosis of patients, and the biological behavior supports its role as a tumor suppressor in gastric cancer.
|
28407749 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Down-regulated OPCML expression might serve as an independent predictor for unfavorable prognosis of patients, and the biological behavior supports its role as a tumor suppressor in gastric cancer.
|
28407749 |
2017 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Down-regulated OPCML expression might serve as an independent predictor for unfavorable prognosis of patients, and the biological behavior supports its role as a tumor suppressor in gastric cancer.
|
28407749 |
2017 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.
|
25189868 |
2015 |
|
Congenital Heart Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects.
|
24616287 |
2014 |
|
Diverticular Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.
|
30177863 |
2018 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
|
30643258 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
|
23966867 |
2013 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
|
23966867 |
2013 |
|
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
|
24529757 |
2014 |
|
Serum albumin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Schizophrenia
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Unipolar Depression
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder.
|
30571770 |
2018 |