|
ovarian neoplasm
|
0.630 |
PosttranslationalModification
|
disease |
BEFREE |
OPCML promoter methylation was significantly associated with an older age of the patients (p=0.022), an advanced pathological stage of ovarian cancer (p=0.023), and poor overall survival of ovarian cancer patients (p<0.001).
|
24327526 |
2014 |
|
ovarian neoplasm
|
0.630 |
PosttranslationalModification
|
disease |
LHGDN |
In all normal ovarian samples OPCML mRNA was present, but it was not detectable in 24 of 43 ovarian cancer cases.
|
17159813 |
2006 |
|
ovarian neoplasm
|
0.630 |
AlteredExpression
|
disease |
LHGDN |
These findings suggest that OPCML is an excellent candidate for the 11q25 ovarian cancer TSG.
|
12819783 |
2003 |
|
ovarian neoplasm
|
0.630 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
ovarian neoplasm
|
0.630 |
CausalMutation
|
disease |
CGI |
|
|
|
|
ovarian neoplasm
|
0.630 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of ovary
|
0.610 |
PosttranslationalModification
|
disease |
BEFREE |
OPCML promoter methylation was significantly associated with an older age of the patients (p=0.022), an advanced pathological stage of ovarian cancer (p=0.023), and poor overall survival of ovarian cancer patients (p<0.001).
|
24327526 |
2014 |
|
Malignant neoplasm of ovary
|
0.610 |
GeneticVariation
|
disease |
UNIPROT |
These findings suggest that OPCML is an excellent candidate for the 11q25 ovarian cancer TSG.
|
12819783 |
2003 |
|
Malignant neoplasm of ovary
|
0.610 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of ovary
|
0.610 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Schizophrenia
|
0.430 |
Biomarker
|
disease |
BEFREE |
We demonstrated a critical role of the schizophrenia-susceptible gene OPCML in spine maturation and cognitive behaviors via regulating the ephrin-EphB2-cofilin signaling pathway, providing further insights into the characteristics of schizophrenia.
|
31577955 |
2019 |
|
Schizophrenia
|
0.430 |
Biomarker
|
disease |
BEFREE |
Growing evidence suggests that the IgLON family of neural adhesion molecules LSAMP, NTM, NEGR1, and OPCML are important candidates in forming the susceptibility to schizophrenia (SCZ).
|
29434535 |
2018 |
|
Schizophrenia
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Schizophrenia
|
0.430 |
Biomarker
|
disease |
BEFREE |
Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population.
|
21833655 |
2012 |
|
Schizophrenia
|
0.430 |
Biomarker
|
disease |
PSYGENET |
Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population.
|
21833655 |
2012 |
|
Ovarian Carcinoma
|
0.300 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Neoplasm of uncertain or unknown behavior of ovary
|
0.300 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Also, we show that high OPCML expression is associated with better response to lapatinib therapy in breast cancer patients and better survival in HER2-overexpressing ovarian cancer patients, suggesting that OPCML co-therapy could be a valuable sensitizing approach to RTK inhibitors.<i></i>.
|
28775148 |
2017 |
|
Breast Carcinoma
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions.
|
31316070 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Unexpectedly, OPCML expression was downregulated in Grade 3 tumor in comparison to other groups signifying that downregulation of OPCML expression may lead to higher grade of tumor formation at the time of diagnosis of ESCC in patients.
|
30880778 |
2019 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
|
30643258 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, the present study has shown that OPCML, which acts as a tumor suppressor, was silenced in gastric cancer cell lines via aberrant hypermethylation of the promoter CpG islands, which may provide a novel molecular approach for the early diagnosis of gastric cancer.
|
29805691 |
2018 |