|
Prostate specific antigen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
|
28139693 |
2017 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Similarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts.
|
21750575 |
2011 |
|
Dyslexia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1.
|
11901358 |
2002 |
|
Reading Disabilities
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data therefore suggest that linkage with reading disability at 2p12-16 is not caused by coding variants of SEMA4F or OTX1.
|
11901358 |
2002 |
|
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Similarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts.
|
21750575 |
2011 |
|
Bladder Exstrophy and Epispadias Complex
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Subject-1 with BEEC had the smallest deletion (66 kb), which deleted only one copy of OTX1.
|
25203062 |
2014 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We have demonstrated that the differential gene expression for both OTX1 and OTX2 genes might be a useful molecular marker to distinguish the different types of sinonasal tumors.
|
30882801 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
|
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a strategy to define the embryonic origin and neurochemical phenotype of cells in this disease, we probed specimens (n = 10) resected during epilepsy surgery with a panel of 13 antibodies recognizing proteins associated with (i) specific progenitor cell types including brain lipid binding protein (BLBP), collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx2, GFAPdelta, MASH1, Otx1, Pax6, vimentin and phosphorylated vimentin and (ii) excitatory or inhibitory neurochemical phenotypes such as the vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).
|
17711980 |
2007 |
|
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Otx1 null mice exhibit spontaneous epileptic seizures and multiple abnormalities affecting primarily the dorsal telencephalic cortex and components of the acoustic and visual sense organs.
|
10068635 |
1999 |
|
Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells.
|
30066897 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion.
|
30066897 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study.
|
28049011 |
2017 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study.
|
28049011 |
2017 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The current results enabled the authors to identify novel potential therapeutic targets and biomarkers in E-ACC and M-ACC individually, with the implication that EN1, DLX6, and OTX1 (orthodenticle homeobox 1) are potential drivers of these cancers.Cancer 2016;122:1513-22.© 2016 American Cancer Society.
|
26953815 |
2016 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas.
|
28348423 |
2017 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using sodium-bisulfite-based approaches, 12 CpG islands (associated with the BARHL2, EVX2, IRX2, MEIS1, MSX1, NR2E1, OC2, OSR1, OTX1, PAX6, TFAP2A, and ZNF577 genes) were confirmed to be methylated in 85% to 100% of the squamous cell carcinomas and 11 CpG islands (associated with the CHAD, DLX4, GRIK2, KCNG3, NR2E1, OSR1, OTX1, OTX2, PROX1, RUNX1, and VAX1 genes) were methylated in >80% of the adenocarcinomas.
|
22143938 |
2012 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, the inhibition of OTX1 led to increased GC cell apoptosis by upregulating cleaved PARP, cleaved caspase‑3 and Bax.
|
30066897 |
2018 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Otx1-null mice have seizures, prepubescent transient growth retardation and gonadal defects.
|
25203062 |
2014 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |