|
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Otx1 null mice exhibit spontaneous epileptic seizures and multiple abnormalities affecting primarily the dorsal telencephalic cortex and components of the acoustic and visual sense organs.
|
10068635 |
1999 |
|
Epileptic Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Otx1 null mice exhibit spontaneous epileptic seizures and multiple abnormalities affecting primarily the dorsal telencephalic cortex and components of the acoustic and visual sense organs.
|
10068635 |
1999 |
|
Dyslexia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1.
|
11901358 |
2002 |
|
Reading Disabilities
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data therefore suggest that linkage with reading disability at 2p12-16 is not caused by coding variants of SEMA4F or OTX1.
|
11901358 |
2002 |
|
Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Northern blot (n = 10) and reverse transcriptase-polymerase chain reaction (n = 45) analyses demonstrated that virtually all medulloblastomas expressed OTX1, OTX2, or both.
|
16462208 |
2006 |
|
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a strategy to define the embryonic origin and neurochemical phenotype of cells in this disease, we probed specimens (n = 10) resected during epilepsy surgery with a panel of 13 antibodies recognizing proteins associated with (i) specific progenitor cell types including brain lipid binding protein (BLBP), collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx2, GFAPdelta, MASH1, Otx1, Pax6, vimentin and phosphorylated vimentin and (ii) excitatory or inhibitory neurochemical phenotypes such as the vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).
|
17711980 |
2007 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OTX1 has been described as a critical molecule for axon refinement in the developing cerebral cortex of mice, and its activity in breast cancer suggests a synergistic function with p53 in CSC differentiation.
|
21478910 |
2011 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OTX1 has been described as a critical molecule for axon refinement in the developing cerebral cortex of mice, and its activity in breast cancer suggests a synergistic function with p53 in CSC differentiation.
|
21478910 |
2011 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Similarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts.
|
21750575 |
2011 |
|
Pervasive Development Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
We molecularly characterized two such deletions, selecting two genes in this region, exportin 1 (XPO1) and orthodenticle homolog 1 (OTX1) for association studies in three North American cohorts (Autism Spectrum Disorder - Canadian American Research Consortium (ASD-CARC), New York, and Autism Genetic Resource Exchange (AGRE)) and one Italian cohort (Società Italiana per la Ricerca e la Formazione sull'Autismo (SIRFA)) of families with ASD.
|
21750575 |
2011 |
|
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Similarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts.
|
21750575 |
2011 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using sodium-bisulfite-based approaches, 12 CpG islands (associated with the BARHL2, EVX2, IRX2, MEIS1, MSX1, NR2E1, OC2, OSR1, OTX1, PAX6, TFAP2A, and ZNF577 genes) were confirmed to be methylated in 85% to 100% of the squamous cell carcinomas and 11 CpG islands (associated with the CHAD, DLX4, GRIK2, KCNG3, NR2E1, OSR1, OTX1, OTX2, PROX1, RUNX1, and VAX1 genes) were methylated in >80% of the adenocarcinomas.
|
22143938 |
2012 |
|
Proliferative vitreoretinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PVR samples showed little or no expression of Otx1 and variable expression of VEGF-A, Otx2, Otx3, p53, and p63 genes.
|
24227910 |
2013 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro.
|
24388989 |
2014 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro.
|
24388989 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Otx1-null mice have seizures, prepubescent transient growth retardation and gonadal defects.
|
25203062 |
2014 |
|
Bladder Exstrophy and Epispadias Complex
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Subject-1 with BEEC had the smallest deletion (66 kb), which deleted only one copy of OTX1.
|
25203062 |
2014 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The current results enabled the authors to identify novel potential therapeutic targets and biomarkers in E-ACC and M-ACC individually, with the implication that EN1, DLX6, and OTX1 (orthodenticle homeobox 1) are potential drivers of these cancers.Cancer 2016;122:1513-22.© 2016 American Cancer Society.
|
26953815 |
2016 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
The current results enabled the authors to identify novel potential therapeutic targets and biomarkers in E-ACC and M-ACC individually, with the implication that EN1, DLX6, and OTX1 (orthodenticle homeobox 1) are potential drivers of these cancers.Cancer 2016;122:1513-22.© 2016 American Cancer Society.
|
26953815 |
2016 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Orthodenticlehomeobox 1 (OTX1) overexpression had previously been associated with the progression of several tumors.
|
27478331 |
2016 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of OTX1 was positively correlated with nodal metastasis status (P = 0.009) and TNM staging (P = 0.001) in HCC tissues.
|
27478331 |
2016 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of OTX1 was positively correlated with nodal metastasis status (P = 0.009) and TNM staging (P = 0.001) in HCC tissues.
|
27478331 |
2016 |