|
Prostate specific antigen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
|
28139693 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We have demonstrated that the differential gene expression for both OTX1 and OTX2 genes might be a useful molecular marker to distinguish the different types of sinonasal tumors.
|
30882801 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells.
|
30066897 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Orthodenticlehomeobox 1 (OTX1) overexpression had previously been associated with the progression of several tumors.
|
27478331 |
2016 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro.
|
24388989 |
2014 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We selected nasal and sinonasal adenocarcinomas to investigate the expression of OTX1 and OTX2 genes through immunohistochemical and real-time PCR analyses.Both OTX1 and OTX2 were absent in all the samples of sinonasal Intestinal-Type Adenocarcinomas (ITACs).
|
30882801 |
2019 |
|
Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Olfactory Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
OTX1 mRNA was identified only in Non-Intestinal Type Adenocarcinomas (NITACs) while OTX2 mRNA was expressed only in Olfactory Neuroblastomas (ONs).
|
30882801 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells.
|
30066897 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion.
|
30066897 |
2018 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas.
|
28348423 |
2017 |
|
Olfactory Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas.
|
28348423 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of OTX1 was positively correlated with nodal metastasis status (P = 0.009) and TNM staging (P = 0.001) in HCC tissues.
|
27478331 |
2016 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro.
|
24388989 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
|
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a strategy to define the embryonic origin and neurochemical phenotype of cells in this disease, we probed specimens (n = 10) resected during epilepsy surgery with a panel of 13 antibodies recognizing proteins associated with (i) specific progenitor cell types including brain lipid binding protein (BLBP), collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx2, GFAPdelta, MASH1, Otx1, Pax6, vimentin and phosphorylated vimentin and (ii) excitatory or inhibitory neurochemical phenotypes such as the vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).
|
17711980 |
2007 |
|
Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Northern blot (n = 10) and reverse transcriptase-polymerase chain reaction (n = 45) analyses demonstrated that virtually all medulloblastomas expressed OTX1, OTX2, or both.
|
16462208 |
2006 |
|
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Otx1 null mice exhibit spontaneous epileptic seizures and multiple abnormalities affecting primarily the dorsal telencephalic cortex and components of the acoustic and visual sense organs.
|
10068635 |
1999 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RESULTS As a result, we identified a total of 263 dysregulated genes that may participate in the metastasis of ccRCC, and established a predictive signature relying on the expression of OTX1, MATN4, PI3, ERVV-2, and NFE4, which could serve as significant progressive and prognostic biomarkers for ccRCC.
|
31194719 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, the inhibition of OTX1 led to increased GC cell apoptosis by upregulating cleaved PARP, cleaved caspase‑3 and Bax.
|
30066897 |
2018 |