|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In addition, silencing the expression of PFTK1 endowed NSCLC cells with decreased migration and invasion abilities, as well as epithelial-mesenchymal transition (EMT) progress in A549 cells.
|
27458099 |
2016 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The serine/threonine-protein kinase PFTAIRE 1 (PFTK1) is a member of the cyclin‑dependent kinase family that is highly expressed in several malignant tumors, including hepatocellular carcinoma, esophageal, breast and gastric cancers, and glioma.
|
28498444 |
2017 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Overall, our results show that miR-613 inhibits glioma cell proliferation and invasion by downregulating CDK14, suggesting that miR-613 and CDK14 may serve as potential therapeutic targets for the treatment of glioma.
|
29289838 |
2018 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These data show that PFTK1 may participate in the pathogenic process of glioma, suggesting that PFTK1 can become a potential therapeutic strategy for gastric cancer.
|
26234562 |
2015 |
|
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study found the critical regulation of OIP5-AS1/miR-223/CDK14 axis on osteosarcoma tumorigenesis, indicating the tumor promoting role of OIP5-AS1 for osteosarcoma.
|
30119217 |
2018 |
|
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, the essential role of CDK14 and the molecular mechanisms by which miRNAs regulate CDK14 in the oncogenesis and progression of OS have not been fully elucidated.
|
29022909 |
2017 |
|
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In summary, these data prove that LINC00858/miR-139/CDK14 axis promotes the tumorigenesis of osteosarcoma, providing a new mechanism or target for osteosarcoma.
|
29944887 |
2018 |
|
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
In summary, these data prove that LINC00858/miR-139/CDK14 axis promotes the tumorigenesis of osteosarcoma, providing a new mechanism or target for osteosarcoma.
|
29944887 |
2018 |
|
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, the essential role of CDK14 and the molecular mechanisms by which miRNAs regulate CDK14 in the oncogenesis and progression of OS have not been fully elucidated.
|
29022909 |
2017 |
|
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study found the critical regulation of OIP5-AS1/miR-223/CDK14 axis on osteosarcoma tumorigenesis, indicating the tumor promoting role of OIP5-AS1 for osteosarcoma.
|
30119217 |
2018 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings suggest a mechanism by which DYRK2 controls CDK14 expression to regulate tumor cell proliferation and invasion in breast cancer.
|
29193658 |
2018 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our findings supported the notion that up-regulated PFTK1 might promote breast cancer progression and metastasis by activating Wnt signaling pathway through the PFTK1-DVL2-β-catenin axis.
|
26033031 |
2015 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our finding revealed miR-455 inhibits breast cancer cell proliferation through targeting CDK14, it might be a target for breast cancer therapy.
|
28300591 |
2017 |
|
ovarian neoplasm
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, our study suggested that PFTK1 played an important role in ovarian cancer development.
|
26772918 |
2016 |
|
ovarian neoplasm
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggest that miR-542-3p functions as a tumor-suppressive miRNA in ovarian cancer by directly targeting CDK14.
|
30557834 |
2019 |
|
ovarian neoplasm
|
0.030 |
Biomarker
|
disease |
BEFREE |
CDK14 suppression-mediated Wnt signaling pathway can inhibit cell proliferation, invasion and migration in ovarian cancer.
|
27505004 |
2017 |
|
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggest that miR-542-3p functions as a tumor-suppressive miRNA in ovarian cancer by directly targeting CDK14.
|
30557834 |
2019 |
|
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
CDK14 suppression-mediated Wnt signaling pathway can inhibit cell proliferation, invasion and migration in ovarian cancer.
|
27505004 |
2017 |
|
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, our study suggested that PFTK1 played an important role in ovarian cancer development.
|
26772918 |
2016 |
|
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, the essential role of CDK14 and the molecular mechanisms by which miRNAs regulate CDK14 in the oncogenesis and progression of OS have not been fully elucidated.
|
29022909 |
2017 |
|
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study found the critical regulation of OIP5-AS1/miR-223/CDK14 axis on osteosarcoma tumorigenesis, indicating the tumor promoting role of OIP5-AS1 for osteosarcoma.
|
30119217 |
2018 |
|
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In summary, these data prove that LINC00858/miR-139/CDK14 axis promotes the tumorigenesis of osteosarcoma, providing a new mechanism or target for osteosarcoma.
|
29944887 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
CDK14 suppression-mediated Wnt signaling pathway can inhibit cell proliferation, invasion and migration in ovarian cancer.
|
27505004 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, our study suggested that PFTK1 played an important role in ovarian cancer development.
|
26772918 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggest that miR-542-3p functions as a tumor-suppressive miRNA in ovarian cancer by directly targeting CDK14.
|
30557834 |
2019 |