|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.
|
30020498 |
2018 |
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Defective differentiation of adipose precursor cells from lipodystrophic mice lacking perilipin 1.
|
25695774 |
2015 |
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.
|
30020498 |
2018 |
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
Perilipin deficiency and autosomal dominant partial lipodystrophy.
|
21345103 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we aimed to investigate lipid droplet protein (CIDEC/FSP27 and perilipinA (PLIN1)) gene expression in human adipose tissue in association with obesity, insulin resistance and mitochondrial gene expression.
|
24126816 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to examine the association between common variants at the PLIN1 gene and central obesity in unrelated Chinese adults.
|
25529448 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data support the hypothesis that the PLIN locus may be a significant genetic determinant for obesity risk in whites and that women are more sensitive to the genetic effects of perilipin than men.
|
15601970 |
2004 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Thus, perilipin was elevated in obese subjects, perhaps as a compensatory mechanism to limit basal lipolysis.
|
15001633 |
2004 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis.
|
28860604 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS.
|
19782423 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Only in women, PLIN1 and PLIN4 variant alleles (6209C and 11482A) were associated with a lower obesity risk [Odds ratio (OR) = 0.58, 95% confidence interval (CI): 0.38-0.93 and OR = 0.56, 95% CI: 0.36-0.89, respectively].
|
15355432 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The variations in perilipin gene (PLIN) were previously associated with obesity and insulin sensitivity.
|
18356850 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Perilipin protein content and lipolysis rates were measured in human subcutaneous fat cells of non-obese (n=10) and obese (n=117) women.
|
12802495 |
2003 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, perilipin was elevated in obese subjects, perhaps as a compensatory mechanism to limit basal lipolysis.
|
15001633 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show: (1) A strong association between rs9939609 SNP of the FTO gene variant and obesity in Spanish morbidly obese adult patients; (2) positive correlations between FTO mRNA and leptin, perilipin, and visfatin gene expressions in subcutaneous adipose tissue; (3) FTO and perilipin gene expressions were positively correlated in visceral fat depot.
|
18855084 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings support an important role for PLIN as a candidate gene for obesity risk in humans as well as a modulator of dietary response to therapies aimed to reduce body weight and decrease metabolic syndrome risk.
|
17353663 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among them, adiponectin (ADIPOQ) and perilipin (PLIN) polymorphisms are major factors of obesity.
|
20495294 |
2010 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity-associated inflammation triggers an autophagy-lysosomal response in adipocytes and causes degradation of perilipin 1.
|
30741926 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The PLIN 6 polymorphism of the perilipin gene may influence the risk of the obesity during adolescence.
|
28274232 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the present study suggests that PCB-138-induced LD enlargement endows adipocytes with resistance to TNF-α-induced cell death and that Fsp27, perilipin, and survivin, at least in part, help adipocytes to sustain enlarged LDs, contributing to the induction of obesity.
|
29704545 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Depot-specific differences in perilipin mRNA but not protein expression in obesity.
|
15078502 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether dietary macronutrients (e.g. carbohydrates and fats) modulated the associations of the common PLIN 11482G > A (rs894160) single nucleotide polymorphism with obesity.
|
18806092 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese.
|
15601966 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population.
|
15770500 |
2005 |