|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we aimed to investigate lipid droplet protein (CIDEC/FSP27 and perilipinA (PLIN1)) gene expression in human adipose tissue in association with obesity, insulin resistance and mitochondrial gene expression.
|
24126816 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to examine the association between common variants at the PLIN1 gene and central obesity in unrelated Chinese adults.
|
25529448 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data support the hypothesis that the PLIN locus may be a significant genetic determinant for obesity risk in whites and that women are more sensitive to the genetic effects of perilipin than men.
|
15601970 |
2004 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis.
|
28860604 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS.
|
19782423 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Only in women, PLIN1 and PLIN4 variant alleles (6209C and 11482A) were associated with a lower obesity risk [Odds ratio (OR) = 0.58, 95% confidence interval (CI): 0.38-0.93 and OR = 0.56, 95% CI: 0.36-0.89, respectively].
|
15355432 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The variations in perilipin gene (PLIN) were previously associated with obesity and insulin sensitivity.
|
18356850 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Perilipin protein content and lipolysis rates were measured in human subcutaneous fat cells of non-obese (n=10) and obese (n=117) women.
|
12802495 |
2003 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, perilipin was elevated in obese subjects, perhaps as a compensatory mechanism to limit basal lipolysis.
|
15001633 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show: (1) A strong association between rs9939609 SNP of the FTO gene variant and obesity in Spanish morbidly obese adult patients; (2) positive correlations between FTO mRNA and leptin, perilipin, and visfatin gene expressions in subcutaneous adipose tissue; (3) FTO and perilipin gene expressions were positively correlated in visceral fat depot.
|
18855084 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings support an important role for PLIN as a candidate gene for obesity risk in humans as well as a modulator of dietary response to therapies aimed to reduce body weight and decrease metabolic syndrome risk.
|
17353663 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among them, adiponectin (ADIPOQ) and perilipin (PLIN) polymorphisms are major factors of obesity.
|
20495294 |
2010 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity-associated inflammation triggers an autophagy-lysosomal response in adipocytes and causes degradation of perilipin 1.
|
30741926 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The PLIN 6 polymorphism of the perilipin gene may influence the risk of the obesity during adolescence.
|
28274232 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the present study suggests that PCB-138-induced LD enlargement endows adipocytes with resistance to TNF-α-induced cell death and that Fsp27, perilipin, and survivin, at least in part, help adipocytes to sustain enlarged LDs, contributing to the induction of obesity.
|
29704545 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Depot-specific differences in perilipin mRNA but not protein expression in obesity.
|
15078502 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether dietary macronutrients (e.g. carbohydrates and fats) modulated the associations of the common PLIN 11482G > A (rs894160) single nucleotide polymorphism with obesity.
|
18806092 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese.
|
15601966 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population.
|
15770500 |
2005 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since the haplotype of the minor alleles PLIN1-4, PLIN5-7 and PLIN6, was related to body-weight regulation at a lower level of body-weight in the men as well in the women we conclude that the PLIN1-4, 6, and 5-7 locus appears as a genetic influencer of obesity risk in humans.
|
19385027 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome.
|
18326614 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression.
|
20163070 |
2009 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Some studies shown that lower level of perilipin protein was displayed in obese than lean subjects and polymorphisms in PLIN were associated with obesity in American and Spanish white women as well as in Korean .
|
18777456 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms at the perilipin (PLIN) locus have been investigated for their potential utility as markers for obesity and metabolic syndrome (MS).
|
18812483 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to evaluate the influence of UCP3, PLIN1 and PPARG2 genes on the substrates oxidation in women with grade III obesity after hypocaloric dietary intervention.
|
28651828 |
2018 |