|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.
|
30020498 |
2018 |
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.
|
30020498 |
2018 |
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Defective differentiation of adipose precursor cells from lipodystrophic mice lacking perilipin 1.
|
25695774 |
2015 |
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
Perilipin deficiency and autosomal dominant partial lipodystrophy.
|
21345103 |
2011 |
|
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity-associated inflammation triggers an autophagy-lysosomal response in adipocytes and causes degradation of perilipin 1.
|
30741926 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the present study suggests that PCB-138-induced LD enlargement endows adipocytes with resistance to TNF-α-induced cell death and that Fsp27, perilipin, and survivin, at least in part, help adipocytes to sustain enlarged LDs, contributing to the induction of obesity.
|
29704545 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to evaluate the influence of UCP3, PLIN1 and PPARG2 genes on the substrates oxidation in women with grade III obesity after hypocaloric dietary intervention.
|
28651828 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis.
|
28860604 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The PLIN 6 polymorphism of the perilipin gene may influence the risk of the obesity during adolescence.
|
28274232 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In recent research, it has been shown that rs2289487 within the PLIN1 gene has different variants that have been associated with obesity, type 2 diabetes, and other diseases.
|
27611592 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to examine the association between common variants at the PLIN1 gene and central obesity in unrelated Chinese adults.
|
25529448 |
2015 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we aimed to investigate lipid droplet protein (CIDEC/FSP27 and perilipinA (PLIN1)) gene expression in human adipose tissue in association with obesity, insulin resistance and mitochondrial gene expression.
|
24126816 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Update on perilipin polymorphisms and obesity.
|
23035807 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among them, adiponectin (ADIPOQ) and perilipin (PLIN) polymorphisms are major factors of obesity.
|
20495294 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Perilipin overexpression in mice protects against diet-induced obesity.
|
19797618 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS.
|
19782423 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show: (1) A strong association between rs9939609 SNP of the FTO gene variant and obesity in Spanish morbidly obese adult patients; (2) positive correlations between FTO mRNA and leptin, perilipin, and visfatin gene expressions in subcutaneous adipose tissue; (3) FTO and perilipin gene expressions were positively correlated in visceral fat depot.
|
18855084 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since the haplotype of the minor alleles PLIN1-4, PLIN5-7 and PLIN6, was related to body-weight regulation at a lower level of body-weight in the men as well in the women we conclude that the PLIN1-4, 6, and 5-7 locus appears as a genetic influencer of obesity risk in humans.
|
19385027 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression.
|
20163070 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants.
|
19399648 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The variations in perilipin gene (PLIN) were previously associated with obesity and insulin sensitivity.
|
18356850 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether dietary macronutrients (e.g. carbohydrates and fats) modulated the associations of the common PLIN 11482G > A (rs894160) single nucleotide polymorphism with obesity.
|
18806092 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome.
|
18326614 |
2008 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Some studies shown that lower level of perilipin protein was displayed in obese than lean subjects and polymorphisms in PLIN were associated with obesity in American and Spanish white women as well as in Korean .
|
18777456 |
2008 |