|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Breakpoint clusters of the PML gene in acute promyelocytic leukemia: primary structure of the reciprocal products of the PML-RARA gene in a patient with t(15;17).
|
7682097 |
1993 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PML tumour suppressor was initially identified as a component of the PML-RARα oncoprotein of acute promyelocytic leukaemia (APL).
|
22359342 |
2012 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecularly, the disease is characterized by a fusion protein, promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha that results from a balanced reciprocal translocation between the PML gene on chromosome 15 and the RAR-alpha (RARA) gene on chromosome 17.
|
19840521 |
2009 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the 398T allele degrades PML tumor suppressor protein more efficiently than the 398C allele and shows a relatively stronger binding to PML.
|
20625391 |
2010 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with acute promyelocytic leukemia (APL), the RARalpha gene is fused with the promyelocytic leukemia (PML) gene via the t(15;17) translocation, resulting in the expression of a PML/RARalpha fusion protein.
|
18212063 |
2008 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed the fusion signals on der(15) and the residual PML signals on der(22).
|
16737919 |
2006 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) has been implicated in a variety of functions, including control of TP53 function and modulation of cellular senescence.
|
16778193 |
2006 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene Knockout Shows That PML (TRIM19) Does Not Restrict the Early Stages of HIV-1 Infection in Human Cell Lines.
|
28656178 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis.
|
30235352 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The promyelocytic leukemia (PML) protein is the core component of nuclear substructures that host more than 70 proteins, termed nuclear domains 10 or PML-nuclear bodies.
|
21501958 |
2011 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infected cells pretreated with siX3, but not siUL54, retained promyelocytic leukemia (PML) protein in cellular PML bodies, an essential component of this host intrinsic antiviral defense.
|
22438545 |
2012 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALT associated PML bodies containing PML protein was found in telomerase negative cases of RCC.
|
25769384 |
2015 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results suggest that EBNA1 usurps two host PML regulators in order to promote degradation of PML proteins and loss of PML NBs.
|
21217204 |
2011 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the imaging characteristics of inflammatory NTZ-PML lesions and PML-IRIS to determine differentiating and overlapping features.
|
29142146 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) is a tumor suppressor and proapoptotic factor.
|
26703467 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Promyelocytic leukemia protein (PML) tumor suppressor is upregulated in several forms of cellular senescence, however the mechanism of its induction is elusive.
|
20699642 |
2010 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall our study designates PML protein and PML-NBs to be major cellular components involved in the control of HSV-1 latency, probably during the entire life of an individual.
|
27618691 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a result, methyl 2,5-dihydromethylcinnimate (2,5-MeC), a tyrosine kinase inhibitor, enhanced expression and/or stability of PML proteins and induced PML-NB formation in p53 null H1299 cells established from non-small cell lung cancer (NSCLC) and wild-type p53-expressing U2OS cells derived from osteosarcoma.
|
17585903 |
2007 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using two different human neuroblastoma cell lines, SH-SY5Y and LA-N-5, we show here that PML protein leads to the formation of nuclear bodies (PML-NB) after only 1 h of retinoic acid treatment and that this formation is mediated by the extracellular signal-regulated kinase (ERK) pathway.
|
17986232 |
2008 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hallmark reciprocal chromosomal translocation t(15;17) involving fusion between the retinoic acid receptor (RARα) gene and promyelocytic leukemia (PML) gene is a characteristic feature in APL which consequently results in the emergence of PML-RARα chimeric gene.
|
29700805 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progressive multifocal leukoencephalopathy [PML], a brain infection associated with anti-integrin drugs that inhibit lymphocyte translocation from bloodstream to tissue, can be fatal.
|
28961770 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
In human cytomegalovirus (HCMV) infection, the IE1 (for "immediate-early 1") protein has a marked effect on PML bodies via de-SUMOylation of PML protein.
|
16870775 |
2006 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
An immunohistochemical study of PML protein in these tumors revealed a disrupted pattern of PML bodies in a nuclear diffuse form, as observed in APL cells.
|
15104675 |
2004 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The occurrence of HIPK domains in PML-/- fibroblasts reveals their independence from the PML protein.
|
12907596 |
2003 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we uncover a novel mechanism of PML gene regulation in which the p38 MAPK and its downstream kinase MAP kinase-activated protein kinase 1 (MNK1) mediate TNFα-induced PML protein accumulation and PML NB formation.
|
26383972 |
2016 |