|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene Knockout Shows That PML (TRIM19) Does Not Restrict the Early Stages of HIV-1 Infection in Human Cell Lines.
|
28656178 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hallmark reciprocal chromosomal translocation t(15;17) involving fusion between the retinoic acid receptor (RARα) gene and promyelocytic leukemia (PML) gene is a characteristic feature in APL which consequently results in the emergence of PML-RARα chimeric gene.
|
29700805 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression.
|
31416160 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
PML protein is essential for formation of PML NBs.
|
30802273 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have recently shown that the promyelocytic leukemia (PML) protein prevents H3.3 from being deposited in large heterochromatic PML-associated domains (PADs).
|
30850162 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
ProMyelocytic Leukemia (PML) protein is essential for the formation of nuclear matrix-associated organelles named PML nuclear bodies (NBs) that act as a platform for post-translational modifications and protein degradation.
|
31153006 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upregulated Mad1 localizes to ProMyelocytic Leukemia (PML) nuclear bodies in breast cancer and cultured cells.
|
30948704 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis.
|
30235352 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the imaging characteristics of inflammatory NTZ-PML lesions and PML-IRIS to determine differentiating and overlapping features.
|
29142146 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progressive multifocal leukoencephalopathy [PML], a brain infection associated with anti-integrin drugs that inhibit lymphocyte translocation from bloodstream to tissue, can be fatal.
|
28961770 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant.
|
29343163 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The promyelocytic leukemia (PML) protein, also known as TRIM19, functions as a major organizer of PML nuclear bodies (NBs) in most mammalian cells and plays important roles in antiviral activities against both DNA and RNA viruses.
|
29922292 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) nuclear bodies (NBs) recruit partner proteins, including p53 and its regulators, thereby controlling their abundance or function.
|
28931625 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, a PML/SLIT1 axis regulates sensitivity to the PML-targeting drug arsenic trioxide in primary GBM cells.
|
28700942 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions.
|
28317833 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report a role of promyelocytic leukemia (PML) protein in the routing of histone variant H3.3 to chromatin and in the organization of megabase-size heterochromatic PML-associated domains that we call PADs.
|
28341773 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer.
|
28332630 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) is a tumor suppressor and proapoptotic factor.
|
26703467 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall our study designates PML protein and PML-NBs to be major cellular components involved in the control of HSV-1 latency, probably during the entire life of an individual.
|
27618691 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we uncover a novel mechanism of PML gene regulation in which the p38 MAPK and its downstream kinase MAP kinase-activated protein kinase 1 (MNK1) mediate TNFα-induced PML protein accumulation and PML NB formation.
|
26383972 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) plays a tumor suppressive role by inducing cellular senescence in response to oncogenic stress.
|
27206849 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALT associated PML bodies containing PML protein was found in telomerase negative cases of RCC.
|
25769384 |
2015 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic Leukemia (PML) Gene Mutations may not Contribute to Gastric Adenocarcinoma Development.
|
25921172 |
2015 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) nuclear bodies are interferon-induced domains, which facilitate sumoylation of a subset of targets.
|
24942926 |
2014 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, elevated levels of PML-NB, PML protein and PML mRNA were detected in the brain tissues from Alzheimer's disease (AD) patients, where γ-secretase activity is essential for pathogenesis.
|
23306558 |
2013 |