|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PML-regulated apoptotic mechanisms in GBM cells transfected with plasmids expressing the PML gene were examined.
|
18812519 |
2009 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progressive multifocal leukoencephalopathy [PML], a brain infection associated with anti-integrin drugs that inhibit lymphocyte translocation from bloodstream to tissue, can be fatal.
|
28961770 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
PML protein is typically localized within discrete speckled nuclear structures termed PML nuclear bodies (NBs).
|
15459016 |
2005 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) has been implicated in a variety of functions, including control of TP53 function and modulation of cellular senescence.
|
16778193 |
2006 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) nuclear bodies are interferon-induced domains, which facilitate sumoylation of a subset of targets.
|
24942926 |
2014 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic Leukemia (PML) Gene Mutations may not Contribute to Gastric Adenocarcinoma Development.
|
25921172 |
2015 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) is a tumor suppressor and proapoptotic factor.
|
26703467 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) plays a tumor suppressive role by inducing cellular senescence in response to oncogenic stress.
|
27206849 |
2016 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions.
|
28317833 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) nuclear bodies (NBs) recruit partner proteins, including p53 and its regulators, thereby controlling their abundance or function.
|
28931625 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis.
|
30235352 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
PML protein is essential for formation of PML NBs.
|
30802273 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
ProMyelocytic Leukemia (PML) protein is essential for the formation of nuclear matrix-associated organelles named PML nuclear bodies (NBs) that act as a platform for post-translational modifications and protein degradation.
|
31153006 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression.
|
31416160 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
AGS GC cells infected with EBV were found to contain fewer PML NBs and less PML protein than the parental EBV-negative AGS cells, and these levels were restored by silencing EBNA1.
|
22013060 |
2012 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALT associated PML bodies containing PML protein was found in telomerase negative cases of RCC.
|
25769384 |
2015 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although it is well defined that PML NB is a site recruiting sumoylated proteins, the mechanism by which PML protein regulates the process remains unclear.
|
19150978 |
2009 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
An immunohistochemical study of PML protein in these tumors revealed a disrupted pattern of PML bodies in a nuclear diffuse form, as observed in APL cells.
|
15104675 |
2004 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a result, methyl 2,5-dihydromethylcinnimate (2,5-MeC), a tyrosine kinase inhibitor, enhanced expression and/or stability of PML proteins and induced PML-NB formation in p53 null H1299 cells established from non-small cell lung cancer (NSCLC) and wild-type p53-expressing U2OS cells derived from osteosarcoma.
|
17585903 |
2007 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Breakpoint clusters of the PML gene in acute promyelocytic leukemia: primary structure of the reciprocal products of the PML-RARA gene in a patient with t(15;17).
|
7682097 |
1993 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant.
|
29343163 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, a PML/SLIT1 axis regulates sensitivity to the PML-targeting drug arsenic trioxide in primary GBM cells.
|
28700942 |
2017 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, elevated levels of PML-NB, PML protein and PML mRNA were detected in the brain tissues from Alzheimer's disease (AD) patients, where γ-secretase activity is essential for pathogenesis.
|
23306558 |
2013 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed a single fusion signal, and RT-PCR analysis showed PML/RARA fusion transcripts.
|
21927800 |
2011 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed the fusion signals on der(15) and the residual PML signals on der(22).
|
16737919 |
2006 |