|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
Cystic Fibrosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PAO1 exoproducts also dampened F508del-CFTR rescue by VRT-325 or Vx-809 correctors in CF cells, whereas PAO1Δ<i>lasR</i> had no impact.Importantly, treatment of <i>P. aeruginosa</i> cultures with a quorum sensing inhibitor (HDMF) prevented the negative effect of <i>P. aeruginosa</i> exoproducts on wt-CFTR and preserved CFTR rescue by correctors in CF AEC.
|
29177135 |
2017 |
|
Cystic Fibrosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this report, we show that mutations in the muc loci, (muc-2, muc-22, and muc-23, in the standard genetic P. aeruginosa strain PAO, as well as a mapped muc allele in an isolate from a cystic fibrosis patient) affect transcription of algD and algR.
|
2140147 |
1990 |
|
Cystic Fibrosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A PAO1ΔoprD mutant was complemented with the oprD genes from five carbapenem-resistant CF strains exhibiting very low amounts of mutated OprD porins in their outer membrane despite wild-type levels of oprD transcripts.
|
25735764 |
2015 |
|
Cystic Fibrosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
By exploiting this unstable phenotype, we isolated 34 spontaneous nonmucoid variants arising from the mucoid strain PDO300, a PAO1 derivative containing the <i>mucA22</i> allele commonly found in mucoid CF isolates.
|
29784885 |
2018 |
|
Cystic Fibrosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using strain PAO1 whole genome DNA microarrays, we assessed the genomic variation in P. aeruginosa strains isolated from young children with CF (6 months to 8 years of age) as well as from the environment.
|
14641578 |
2003 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Reticulocyte count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
|
25188341 |
2014 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Infectious Lung Disorder
|
0.060 |
GeneticVariation
|
group |
BEFREE |
The PAO1 ICL mutant was less virulent in the rat lung infection model, indicating that ICL is required for the pathogenesis of P. aeruginosa in mammals.
|
18524916 |
2008 |
|
Malignant neoplasm of stomach
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.
|
25174398 |
2015 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.
|
25174398 |
2015 |
|
Stomach Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.
|
25174398 |
2015 |
|
Tumor Cell Invasion
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Furthermore, P. aeruginosa PAO1 transformants with the pumA gene increased Caenorhabditis elegans and mouse mortality rate and improved mouse organ invasion, effects neutralized by the PumB protein.
|
28970172 |
2017 |
|
Acute infectious disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Expression of aceA in PAO1, a P. aeruginosa isolate associated with acute infection, is regulated by carbon sources that utilize the glyoxyate pathway.
|
20093293 |
2010 |
|
Middle Cerebral Artery Occlusion
|
0.310 |
Biomarker
|
disease |
CTD_human |
In this study, we found that Smox expression was increased in a rat middle cerebral artery occlusion (MCAO) model and in cultured primary neurons after oxygen-glucose deprivation and reoxygenation (OGD/R).
|
30576531 |
2019 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
CTD_human |
After the onset of stroke, an increase in AcPAO first occurred, followed by increased levels of SMO and finally acrolein.
|
16269634 |
2005 |
|
Middle Cerebral Artery Syndrome
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Targeting Smox Is Neuroprotective and Ameliorates Brain Inflammation in Cerebral Ischemia/Reperfusion Rats.
|
30576531 |
2019 |
|
Mood Disorders
|
0.300 |
Biomarker
|
group |
PSYGENET |
Overall, each gene was associated with at least one main outcome: anxiety (SAT1, SMS), mood disorders (SAT1, SMOX), and suicide attempts (SAT1, OATL1).
|
21152090 |
2010 |