|
Epilepsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analysed the effect of spermine oxidase over-expression in a different epileptic model, pentylenetetrazole.
|
31197571 |
2020 |
|
Epileptic Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The transgenic mouse line Dach-SMOX, with CD1 background, specifically overexpressing spermine oxidase in brain cortex, has been proven to be highly susceptible to epileptic seizures and excitotoxic stress induced by kainic acid.
|
31197571 |
2020 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we investigated trans-PAO's impact on hyperlipidemia-induced inflammation and atherosclerosis progression in these mice.
|
31422082 |
2019 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we investigated trans-PAO's impact on hyperlipidemia-induced inflammation and atherosclerosis progression in these mice.
|
31422082 |
2019 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A significant, inverse correlation between circulating trans-PAO levels and diabetes incidence and cardiovascular mortality has been reported.
|
31422082 |
2019 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A significant, inverse correlation between circulating trans-PAO levels and diabetes incidence and cardiovascular mortality has been reported.
|
31422082 |
2019 |
|
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spermine oxidase: A promising therapeutic target for neurodegeneration in diabetic retinopathy.
|
31207342 |
2019 |
|
Hyperlipidemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we investigated trans-PAO's impact on hyperlipidemia-induced inflammation and atherosclerosis progression in these mice.
|
31422082 |
2019 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, LYZOX was shown to inhibit the growth of P. aeruginosa (NBRC 13275 and PAO1), A. baumannii and MRSA better than its components.
|
31136634 |
2019 |
|
Arthritis, Psoriatic
|
0.010 |
Biomarker
|
disease |
BEFREE |
In lung tissue, increased infiltration of inflammatory cells, elevated lung injury and augmented cellular senescence was shown in mice with CLP followed by sublethal PA infection, and these observations reached a higher rank when higher (H) loads PA (PAO1) were administered to CLP mice (CLP + PAO1-H).
|
30649401 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found loss of the polyamine catabolic enzymes spermidine/spermine-N (1)-acetyltransferase-1 (SAT1) and spermine oxidase (SMOX) predominantly in bronchial epithelial cells (BECs) of human asthmatic lung samples and mice with AAI.
|
29729200 |
2018 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we utilized <i>Smox</i>-deficient mice to examine the role of SMOX in two murine colitis models, <i>Citrobacter rodentium</i> infection and dextran sulfate sodium (DSS)-induced epithelial injury.In <i>C. rodentium</i>-infected wild-type (WT) mice, there were marked increases in colon weight/length and histologic injury, with mucosal hyperplasia and inflammatory cell infiltration; these changes were ameliorated in <i>Smox<sup>-/-</sup></i> mice.
|
29922289 |
2018 |
|
Encephalitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The objective was to analyze neurotrophic and oxidative parameters that could be related to midbrain dopamine neuronal loss or brain inflammation in the CSF of elderly subjects: 1) levels of the dopaminotrophic factors BDNF, GDNF, persephin, and neurturin, 2) levels of the proinflammatory factors TGFβ<sub>1</sub> and TGFβ<sub>2</sub>; 3) activity of main antioxidant enzymes (catalases, glutathione-peroxidase, glutathione-reductase, glutathione-S-transferases, peroxirredoxins, and superoxide-dismutases), 4) ferritin content, antioxidant protein which reduces reactive free iron, and 5) antioxidant potential of the cerebrospinal fluid.ELISA and PAO tests were used.
|
29775745 |
2018 |
|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, we reported that SMOX can be upregulated in humans with inflammatory bowel disease.
|
29922289 |
2018 |
|
Mild Mental Retardation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using a library of phages that infect two different clinical isolates of <i>P. aeruginosa</i>, PAO1 and PA14, we compared the phenotypes imparted by the expression of individual phage morons.
|
30150232 |
2018 |
|
Respiratory Tract Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
This study aimed to evaluate the time course of bacterial killing and resistance of meropenem and ciprofloxacin in combination against hypermutable and nonhypermutable <i>P. aeruginosa</i> Static concentration time-kill experiments over 72 h assessed meropenem and ciprofloxacin in mono- and combination therapies against PAO1 (nonhypermutable), PAOΔ<i>mutS</i> (hypermutable), and hypermutable isolates CW8, CW35, and CW44 obtained from CF patients with chronic respiratory infections.
|
30104278 |
2018 |
|
Sinusitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Insertion of the stent in PAO-1-infected rabbits for 2 weeks resulted in significant improvement in sinusitis according to endoscopy scoring (p < 0.0001) and CT scoring (p < 0.002).
|
29334430 |
2018 |
|
Anemia of prematurity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The effects of AOP treatments on bacterial gene expression was examined using Pseudomonas aeruginosa strain PAO1 as a model-organism bacterium.
|
29448190 |
2018 |
|
Zika Virus Infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This antiviral effect was mediated by the upregulation of two polyamine catabolic enzymes, spermine oxidase, and spermidine (SMOX)/spermine N1-acetyltransferase (SAT1) as apparent reduction of the ZIKV infection following heterologous expression of SMOX and SAT1.
|
30040423 |
2018 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we evaluate the volatile metabolites produced by P. aeruginosa (PAO1)-infected, RSV-infected, co-infected, or uninfected CF bronchial epithelial (CFBE) cells, in vitro.
|
29735804 |
2018 |
|
Muscle fibrosis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Normalization of either Amd1 or Smox expression in dy2j/dy2j TA ameliorates muscle fibrosis, reduces overactive profibrotic TGF-β pathway and leads to improved locomotion.
|
29566247 |
2018 |
|
NONAKA MYOPATHY
|
0.010 |
Biomarker
|
disease |
BEFREE |
P. aeruginosa katA<sup>-</sup> mutant was more sensitive than wild-type strain PAO1 to wide-spectrum light and blue LED (464 nm) treatments.
|
29709605 |
2018 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of SMOX inhibited HCC cell proliferation, arrested cell cycle at S phase, and resulted in an increase of apoptosis.
|
29923661 |
2018 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
6-Hydroxy-l-nicotine (6HLN), a nicotine derivative from nicotine degradation by Arthrobacter nicotinovorans pAO1 strain was found to improve behavioral deficits and to reverse oxidative stress in the rat hippocampus.Rats were given CHL (10mg/kg, i.p.) were used as an Alzheimer's disease-like model.
|
27951416 |
2017 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, treatment with KAAD-cyclopamine or transfection with Smo-siRNA suppressed migration of RA-FLSs and showed an inhibitory effect of Rho GTPase signaling.
|
28261216 |
2017 |