|
Mental disorders
|
0.110 |
Biomarker
|
group |
BEFREE |
Subsequently, we surveyed 900 Colorado PCPs to identify factors associated with PCP self-efficacy in management of mental illness and team-based care.
|
31492096 |
2019 |
|
Hypertensive disease
|
0.110 |
Biomarker
|
group |
BEFREE |
The preferential stimulation of Th17 differentiation by IP signaling may have important clinical implications as PGI(2) and its analogs are commonly used to treat human pulmonary hypertension.
|
22590492 |
2012 |
|
Psychotic Disorders
|
0.110 |
Biomarker
|
group |
BEFREE |
Accumulating evidence shows that mGluR5 antagonists by themselves do not necessarily disrupt pre-pulse inhibition (PPI), but can exacerbate disruption of PPI caused by MK-801 and PCP, while positive modulation of this receptor has beneficial effects on these models of psychosis.
|
18063347 |
2008 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study demonstrates that PRICKLE1 could act as a predisposing factor to human NTDs and further expands our knowledge of the role of PCP genes in the pathogenesis of these malformations.
|
21901791 |
2011 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
Homozygous disruption of PCP genes in mice results in a spectrum of NTDs, including defects that affect the entire neural axis (craniorachischisis), cranial NTDs (exencephaly) and spina bifida.
|
21840926 |
2011 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Additionally, glypicans function in the planar cell polarity (PCP) pathway, and several PCP genes have been associated with NTDs.
|
23223018 |
2013 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
We suggest that other PCP genes should be considered as candidates for a role in the etiology of human NTDs.
|
19129707 |
2009 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Knockout mice that are heterozygotes of single PCP genes likely fail to produce NTD phenotypes, yet damaging variants detected in human NTDs are almost always heterozygous, suggesting that other deleterious interacting variants are likely to be present.
|
29618362 |
2018 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the Wnt/PCP-Jnk-dependent pathway plays an important role in taurine-mediated prevention of NTDs.
|
28718066 |
2017 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
The Looptail (Lp) mutant mouse was the first mammalian mutant implicating a PCP gene (Vangl2) in the pathogenesis of NTD.
|
29063958 |
2018 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In vertebrate embryos undergoing convergent extension (CE), the Planar Cell Polarity (PCP) pathway drives the elongation of the body axis and shapes the central nervous system, and mutations of the PCP genes predispose humans to various malformations including neural tube defects.
|
30579764 |
2019 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we summarize our current understanding of how PCP factors affect the pathogenesis of NTDs.
|
21864354 |
2011 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.
|
24307374 |
2014 |
|
Neoplasm Metastasis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product present in all cells, is an essential enzyme of catabolic glycolysis and anabolic gluconeogenesis, and regulates tumor cell growth and metastasis.
|
17925402 |
2007 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
These results suggest for the first time that PGI/AMF is a key gene to both EMT in the initiating step of cancer metastasis and MET in the later stage of metastasis during breast cancer progression.
|
19531650 |
2009 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
|
31621760 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Mammalian PGI is a multi-functional protein which, besides its glycolytic function, can also act as a cytokine, growth factor and inducer of angiogenesis, and plays a role in tumour growth, development and metastasis formation.
|
20600070 |
2010 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
This newly characterized PARP-14 protein should assist in understanding the regulation of PGI/AMF intracellular function(s) and may provide a new therapeutic target for inhibition of PGI/AMF inducing tumor cell migration and invasion during metastasis.
|
17875708 |
2007 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
PGI is a multifunctional dimeric protein that extracellularly acts as a cytokine with properties that include autocrine motility factor (AMF) eliciting mitogenic, motogenic, differentiation functions and has been implicated in tumor progression and metastasis.
|
16126909 |
2005 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is secreted by tumors and influences tumor growth and metastasis.
|
26936801 |
2016 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, CTHRC1 promotes GIST cell migration and invasion by activating Wnt/PCP-Rho signaling, suggesting that the CTHRC1-Wnt/PCP-Rho axis may be a new therapeutic target for interventions against GIST invasion and metastasis.
|
24726140 |
2014 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) plays an important role in glycolysis and gluconeogenesis and is associated with invasion and metastasis of cancer cells.
|
21389093 |
2011 |
|
Pneumocystis jiroveci pneumonia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our data suggest that core Frizzled/PCP factors, acting through RhoA and Rho kinase, regulate the function/activity of integrins and that integrins thus contribute to the complex interaction network of PCP signalling, cell adhesion and cytoskeletal elements required for a precise and synchronous 90° rotation movement.
|
31409231 |
2019 |
|
Pneumocystis jiroveci pneumonia
|
0.090 |
Biomarker
|
disease |
BEFREE |
A 10-year-old girl was referred to our hospital for the treatment of Pneumocystis Jirovecii Pneumonia (PCP: Pneumocystis pneumonia).
|
29138020 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Pneumocystis pneumonia or PCP is caused by Pneumocystis jirovecii, an obligate parasite of the human lung.
|
15531210 |
2004 |