|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of either microglial activation or CCR2 abolished the PAP-I-induced hyperalgesia.
|
31744864 |
2020 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, PAP-I mediates the neuron-microglial crosstalk after peripheral nerve injury, and contributes to the maintenance of neuropathic pain.<b>SIGNIFICANCE STATEMENT</b>Neuropathic pain is maladaptive pain condition and the maintaining mechanism is largely unclear.
|
31744864 |
2020 |
|
Chronic pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Overall, the present analysis concludes changes in BPI average pain scores by PGI-I category and the cut-off for CID were similar for Asian and Caucasian patients with chronic pain due to osteoarthritis.
|
31505082 |
2020 |
|
Tactile Allodynia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Intrathecal delivery of PAP-I enhanced sensory hyperalgesia, whereas PAP-I deficiency by either gene knockout or antibody application alleviated tactile allodynia at the maintenance phase after SNI.
|
31744864 |
2020 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The patients were randomly assigned into derivation cohort (801cases) and validation cohort (200 cases) in 8:2 ratio, respectively, in which in derivation cohort we found that 7 predictors, including LDH >350U/L, HR>130 times/min, room air PaO<sub>2</sub> <70mmHg, later admission to ICU, Anemia (HGB≤90g/L), CD4<50cells/ul, and development of a pneumothorax, were associated with poor prognosis in HIV/AIDS patients with PCP and were included in the predictive model.
|
30906778 |
2019 |
|
Anthrax disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
According to our results, PCP-I could significantly enhance anthrax specific anti-PA antibodies, toxin-neutralizing antibodies, anti-PA antibody affinity, as well as IgG1 and IgG2a levels.
|
31809637 |
2019 |
|
Congenital Hydrocephalus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this review we would like to discuss the data regarding p73 role as regulator of ependymal cell ciliogenesis and PCP, supporting the view of the <i>Trp73</i>-mutant mice as a model that uncouples ciliogenesis from PCP and a possible model of human congenital hydrocephalus.
|
30930930 |
2019 |
|
Pneumothorax
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The patients were randomly assigned into derivation cohort (801cases) and validation cohort (200 cases) in 8:2 ratio, respectively, in which in derivation cohort we found that 7 predictors, including LDH >350U/L, HR>130 times/min, room air PaO<sub>2</sub> <70mmHg, later admission to ICU, Anemia (HGB≤90g/L), CD4<50cells/ul, and development of a pneumothorax, were associated with poor prognosis in HIV/AIDS patients with PCP and were included in the predictive model.
|
30906778 |
2019 |
|
Migraine Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The Migraine Disability Assessment (MIDAS), Patient Global Impression of Severity (PGI-S), Patient Global Impression of Improvement (PGI-I), and migraine headache days (MHD) served as anchors.
|
30861580 |
2019 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Betaine also showed a prophylactic effect on behavioral abnormality induced by PCP.
|
31255657 |
2019 |
|
Intestinal metaplasia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Compared with patients with extended AG/IM (PGI/II≤3 and/or OGLIM stage III-IV), patients with limited AG/IM (PG I/II>3 and OLGIM stage 0-II) did not develop high-grade adenoma/dysplasia or invasive neoplasia during follow-up (p=0.02).
|
29875257 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa.
|
31621760 |
2019 |
|
Urinary symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The patients' Global Impression of Improvement (PGI-I) and quality of life index (QoL-I) due to urinary symptoms were used for outcome evaluation.
|
30083942 |
2019 |
|
hiv-infection/aids
|
0.010 |
Biomarker
|
disease |
BEFREE |
A predictive model to evaluate mortality in HIV/AIDS patients with PCP was constructed based on routine laboratory and clinical parameters, which may be a simple tool for physicians to assess the prognosis in HIV/AIDS patients with PCP in China.
|
30906778 |
2019 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa.
|
31621760 |
2019 |
|
Epstein-Barr Virus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
EBV infection in situ increased the serum levels of PGI and ratio of PGI/PGII in gastric cancer patients.
|
30053417 |
2018 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mice receiving PCP and saline exhibited deficits in novel object recognition, as expected, while pridopidine treatment counteracted PCP-induced memory impairment.
|
29692729 |
2018 |
|
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mice receiving PCP and saline exhibited deficits in novel object recognition, as expected, while pridopidine treatment counteracted PCP-induced memory impairment.
|
29692729 |
2018 |
|
extranodal lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Primary gastrointestinal non-Hodgkin's lymphoma (PGI NHL) is the most common type of extranodal lymphoma.
|
29764448 |
2018 |
|
Digestive System Non-Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Primary gastrointestinal non-Hodgkin's lymphoma (PGI NHL) is the most common type of extranodal lymphoma.
|
29764448 |
2018 |
|
HIV-1 infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Despite subsequent successful treatment of PCP and HIV-1 infection, we could not save her life due to the intracranial hemorrhage caused by Moyamoya syndrome.
|
29138020 |
2018 |
|
Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
PGII levels increased while PGI/PGII declined with age in a healthy population.<i>H. pylori</i> infection had an effect on raising LDL-C levels to increase the risk of atherosclerosis in males, especially those of elderly age.Age, <i>H. pylori</i> infection, levels of renal function and FBG were associated with levels of pepsinogens and gastrin.
|
28932086 |
2017 |
|
Atherosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
PGII levels increased while PGI/PGII declined with age in a healthy population.<i>H. pylori</i> infection had an effect on raising LDL-C levels to increase the risk of atherosclerosis in males, especially those of elderly age.Age, <i>H. pylori</i> infection, levels of renal function and FBG were associated with levels of pepsinogens and gastrin.
|
28932086 |
2017 |
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
GISTIC analysis of MIP data showed no significant larger chromosomal aberrations but a fraction of ACP showed recurrent focal gains of chromosomal material, other cases showed loss in the chromosomal region Xq28, and a third group and the PCP had stable genomes.
|
28069929 |
2017 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
We conclude that acute PCP induces SCZ-like symptom classes in a dose-dependent manner; PCP doses of 1.0-2.0 mg/kg are more suitable for modeling SCZ-like negative symptoms and cognitive deficits, while SCZ-like positive symptoms dominate at doses of 3.0-5.0 mg/kg.
|
28342897 |
2017 |