Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MAP, rs2241880 (ATG16L1) and rs10045431 (IL12B) were found to be significantly associated with CD.
|
24522266 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the genetic polymorphisms of the autophagy-associated genes autophagy-related 16-like 1 (ATG16L1), immunity-related GTPase M (IRGM), Unc-51-like kinase 1 (ULK1), and NOD2 with respect to early-onset Crohn disease (CD) among Korean children.
|
25944217 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD.
|
20222171 |
2010 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The critical next step is functional characterization of the CD-associated genetic variants in IRGM and ATG16L.
|
17921695 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.
|
19337756 |
2009 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
|
17200669 |
2007 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Conclusion In this meta-analysis, the ATG16L1 genotype was significantly associated with the risk of developing Crohn's disease.
|
27698206 |
2017 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease.
|
17625155 |
2007 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All nine ATG16L1 gene variants analyzed displayed highly significant associations with CD demonstrating a CD-protective effect for the minor allele.
|
18162085 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association of ATG16L1 T300A with CD was confirmed [P = 0.004, odds ratio (OR) = 1.69, 95% CI: 1.19-2.41], and both IL23R variants were found to represent significant risk for the disease (P = 0.008, OR = 2.05, 95% CI: 1.20-3.50 for rs1004819 AA; P < 0.001, OR = 2.97, 95% CI: 1.65-5.33 for rs2201841 CC).
|
20066736 |
2010 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the North American population, PHOX2B, NCF4, FAM92B, and rs224136 are not associated with CD in the European population, whereas NOD2/CARD15, IL23R, and ATG16L1 are strongly associated with CD in both the North American and European populations, confirming these three genes as major CD susceptibility genes in Caucasian populations.
|
19262523 |
2009 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients.
|
29487628 |
2018 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The associated polymorphisms in ATG16L1 and IRGM have been confirmed, and functional studies have begun to shed light on how they link to CD pathogenesis.
|
21830281 |
2012 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Autophagy-related 16 like-1 (ATG16L-1), immunity-related GTPase-M (IRGM), and nucleotide-binding oligomerization domain-containing 2 (NOD2) regulate autophagy, and variants in these genes have been associated with predisposition to Crohn's disease (CD).
|
22285936 |
2012 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found a genetic interaction between reference SNP (rs)2241880 (ATG16L1) and rs10065172 (IRGM) in CD.
|
24247223 |
2013 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical outcomes in thyroid cancer.
|
25645662 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs (rs2241880 and rs6754677) in the ATG16L1 gene were significantly associated with the onset of CD in the Malaysian population.
|
31654602 |
2020 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15; rs2241880 A/G of ATG16L1, and rs11209026 (rs11209026;rs901312933" genes_norm="149233;55054">R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals.
|
20380008 |
2010 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study has shown an association of Crohn's disease with the autophagy related 16-like 1 gene.
|
19026604 |
2009 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ATG16L1 and IL23R variants and genetic susceptibility to crohn's disease: mode of inheritance based on meta-analysis of genetic association studies.
|
25738374 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.
|
17484864 |
2007 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association of CD with ATG16L1 rs2241880 variant in early-onset CD.
|
19659808 |
2009 |