ATG16L1, autophagy related 16 like 1, 55054

N. diseases: 120; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 Biomarker disease CTD_human
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE Twenty one patients with IBD (10 with ulcerative colitis (UC), 11 with Crohn's disease (CD)), seven disease specificity controls (DSC), and seven healthy controls were studied. 11171821 2001
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.200 Biomarker disease BEFREE Twenty one patients with IBD (10 with ulcerative colitis (UC), 11 with Crohn's disease (CD)), seven disease specificity controls (DSC), and seven healthy controls were studied. 11171821 2001
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.200 Biomarker disease BEFREE Seventeen steroid-dependent consecutive patients with IBD (10 UC mean age 36 +/- 12, and 7 Crohn's disease mean age 31 +/- 5) were consecutively recruited. 16494108 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease CTD_human Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 17435756 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. 17200669 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 17554300 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease LHGDN Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. 17625155 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. 17484864 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Recently, positive association of CD with the variants in interleukin 23 receptor (IL23R), autophagy-related 16-like 1 (ATG16L1) genes and chromosome 5p13.1 locus was reported through genome-wide association studies which are now recognised as a robust tool for the identification of susceptibility genes for complex diseases. 17534574 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population. 17894849 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB Systematic association mapping identifies NELL1 as a novel IBD disease gene. 17684544 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 17554300 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease LHGDN We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population. 17894849 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 17435756 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease LHGDN A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. 17200669 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE We confirmed the findings that ATG16L1 is a CD susceptibility gene and found no evidence of interaction with CARD15, IL23R, or IBD5. 17455206 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease LHGDN A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. 17484864 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 17435756 2007
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 17435756 2007
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. 17200669 2007
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. 17484864 2007
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.500 Biomarker group LHGDN No significant association was observed between IL23R genotype or ATG16L1 genotype and IBD subphenotypes. 17894849 2007
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.500 Biomarker group BEFREE The association of ATG16L1 with Crohn's disease and possibly with ulcerative colitis supports a role for autophagy in the pathogenesis of inflammatory bowel disease. 17484864 2007