|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this review, we summarize recent studies on the CD-associated NOD2, ATG16L1 and IRGM risk variants and their contribution to the autophagy functions that have most influenced our understanding of CD pathophysiology.
|
23328432 |
2013 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There is a significant association of CD with the single nucleotide polymorphisms (SNPs) in ATG16L1 (odds ratio [OR] 1.36 [1.15-1.60], P = 2.7 × 10(-6) for allele G), IRGM (OR 1.56 [1.21-1.93], P = 3.9 × 10(-4) for allele C), and ITLN1 (OR 1.55 [1.28-1.88], P = 4.9 × 10(-4) for allele C).
|
22573572 |
2013 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Epistasis analysis showed weak epistasis between the ATG16L1 SNP rs2241879 and PTPN2 SNP rs2542151 (p = 0.024) in CD and between ATG16L1 SNP rs4663396 and PTPN2 SNP rs7234029 (p = 4.68×10⁻³) in UC.
|
22457781 |
2012 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities.
|
28466260 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Importantly, Crohn's disease patients homozygous for the ATG16L1 Crohn's disease risk allele displayed Paneth cell granule abnormalities similar to those observed in autophagy-protein-deficient mice and expressed increased levels of leptin protein.
|
18849966 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently, positive association of CD with the variants in interleukin 23 receptor (IL23R), autophagy-related 16-like 1 (ATG16L1) genes and chromosome 5p13.1 locus was reported through genome-wide association studies which are now recognised as a robust tool for the identification of susceptibility genes for complex diseases.
|
17534574 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirm the association of the ATG16L1 variant and IRGM variants with Crohn's disease.
|
20395867 |
2010 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population.
|
17894849 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients.
|
25253126 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this review, we focus on the importance of ATG16L1 and its genetic variant (T300A) within the elementary biological processes linked to Crohn disease.
|
25906181 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Epistasis detected between 5p13.1 and ATG16L1 for CD susceptibility in the discovery cohort (p = 5.99×10⁻⁷ for rs7720838 and rs2241880) could not be replicated in both replication cohorts arguing against a major role of this gene-gene interaction in the susceptibility to CD.
|
23300802 |
2012 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In patients, the CD-associated ATG16L1 T300A single-nucleotide polymorphism did not attenuate azathioprine induction of autophagy.
|
30889246 |
2019 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here we demonstrate that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice.
|
20602997 |
2010 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Most cases were male (55.4%), had disease location L3 +/- L4 (56.7%), and an inflammatory phenotype B1 +/- p (87.2%) at diagnosis. rs2241880 (ATG16L1) was strongly associated with CD (allelic P = 1.24 x 10(-6)).
|
18985712 |
2009 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Neither the other two NOD2 variants, nor the known variants in IL23R and ATG16L1 were found to be risk factors for CD, UC or IBD.
|
20082483 |
2010 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This interest has been substantiated by genome-wide association studies with the identification of genetic association between Crohn's disease and variants in two separate autophagy genes, ATG16L1 and IRGM.
|
22796792 |
2012 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Multivariate analysis showed independent CD association for carriers of ATG16L1 (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.09-3.24), IBD5-IGR2230 (OR = 2.16, 95% CI 1.30-3.59), and IL23R-rs10889677 (OR = 2.13, 95% CI 1.39-3.28) while retaining association for NOD2 mutation carriers (OR = 4.45, 95% CI 2.68-7.38), IBD family history (OR = 2.75, 95% CI 1.42-5.31), tobacco (OR = 2.06, 95% CI 1.35-3.14), and Jewish ethnicity (OR = 20.1, 95% CI 2.16-186.8).
|
18521914 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Five hundred eighteen Dutch white IBD patients (311 CD and 207 UC, including 176 trios of patients with both parents), 508 celiac disease patients, and 893 healthy controls were studied for association with the rs11209026 (IL23R) and rs2241880 (ATG16L1) single nucleotide polymorphisms (SNP).
|
18047540 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An alteration in ATG16L1 stability in Crohn disease.
|
25136803 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, variants of ATG16L1 (WT: 2.03 ± 0.19 vs homozygoot variant: 4.38 ± 0.37, P < 0.009) as well as NOD2 (C-ins) (heterozygous variant: 42.08 ± 2.94 vs homozygous variant: 75.58 ± 4.34 (P = 0.05) are associated with the phagocytic activity in patients with CD.
|
24627602 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |