Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
LHGDN |
The association of ATG16L1 with Crohn's disease and possibly with ulcerative colitis supports a role for autophagy in the pathogenesis of inflammatory bowel disease.
|
17484864 |
2007 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
No significant association was observed between IL23R genotype or ATG16L1 genotype and IBD subphenotypes.
|
17894849 |
2007 |
Crohn's disease of the ileum
|
0.310 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
Crohn's disease of large bowel
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
Regional enteritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
IIeocolitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IL23R was associated with CD and UC only in the absence of CARD15 mutations, whereas ATG16L1 was associated with CD in the presence and absence of CARD15 mutations.
|
17894849 |
2007 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1 risk genotype showed a modest but significant association with ulcerative colitis (P = .026).
|
17484864 |
2007 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
LHGDN |
The ATG16L1 risk genotype showed a modest but significant association with ulcerative colitis (P = .026).
|
17484864 |
2007 |
Pediatric Crohn's disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
The use of techniques such as whole genome association studies to perform broad, unbiased screening for the contributions of common genetic variations to complex disease has rapidly assisted in the identification of several novel susceptibility loci associated with pediatric-onset Crohn's disease such as IL23R and ATG16L1.
|
17600381 |
2007 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
With the recent completion of the human genome project, whole genome association studies (WGAS) have now become possible and have identified additional genes (IL23R, IRGM, PTGER4, ATG16L1) for Crohn's disease and ulcerative colitis, that have subsequently been replicated.
|
18473763 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The critical next step is functional characterization of the CD-associated genetic variants in IRGM and ATG16L.
|
17921695 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All nine ATG16L1 gene variants analyzed displayed highly significant associations with CD demonstrating a CD-protective effect for the minor allele.
|
18162085 |
2008 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.
|
18438406 |
2008 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
LHGDN |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
LHGDN |
Thus, we propose that the association of ATG16L1*300A with increased risk of Crohn's disease is due to impaired bacterial handling and lowered rates of bacterial capture by autophagy.
|
18852889 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Importantly, Crohn's disease patients homozygous for the ATG16L1 Crohn's disease risk allele displayed Paneth cell granule abnormalities similar to those observed in autophagy-protein-deficient mice and expressed increased levels of leptin protein.
|
18849966 |
2008 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
There was no association with any of the known CD susceptibility loci (NOD2, IBD5, NOD1, IL23R, ATG16L1) and isolated colonic CD.
|
18521924 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Multivariate analysis showed independent CD association for carriers of ATG16L1 (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.09-3.24), IBD5-IGR2230 (OR = 2.16, 95% CI 1.30-3.59), and IL23R-rs10889677 (OR = 2.13, 95% CI 1.39-3.28) while retaining association for NOD2 mutation carriers (OR = 4.45, 95% CI 2.68-7.38), IBD family history (OR = 2.75, 95% CI 1.42-5.31), tobacco (OR = 2.06, 95% CI 1.35-3.14), and Jewish ethnicity (OR = 20.1, 95% CI 2.16-186.8).
|
18521914 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Five hundred eighteen Dutch white IBD patients (311 CD and 207 UC, including 176 trios of patients with both parents), 508 celiac disease patients, and 893 healthy controls were studied for association with the rs11209026 (IL23R) and rs2241880 (ATG16L1) single nucleotide polymorphisms (SNP).
|
18047540 |
2008 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Several promising associations between Crohn's disease and gene variants have been identified and replicated, the two most widely replicated being variants in the IL23R and ATG16L1 genes.
|
18622155 |
2008 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATG16L1 and NOD2 were found to contribute independently to CD risk.
|
18671817 |
2008 |