|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
|
17151091 |
2007 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
|
19047118 |
2008 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors.
|
16174078 |
2005 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer.
|
15173859 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.
|
15753380 |
2005 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Levels of COX-2 mRNA are found over-expressed in almost 80% of the colorectal tumors, compared to paired adjacent normal colorectal mucosa, suggesting a role of COX-2 as a potential biomarker for cancer risk, whereas inhibitors of COX-2 could be of value in chemoprevention of colon cancer.
|
24383454 |
2014 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2.
|
12837940 |
2003 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms.
|
12494894 |
2003 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases.
|
15248379 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Cyclooxygenase-2 expression and angiogenesis in colorectal cancer.
|
12800231 |
2003 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention.
|
20427397 |
2010 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells.
|
16237757 |
2005 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Bioactive metabolites downstream of cyclooxygenase-2 (COX-2) generated prostaglandin H(2) (PGH(2)), in particular prostaglandin E(2) (PGE(2)), are thought to play critical roles during the development of colorectal tumors.
|
19035518 |
2009 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
|
16820091 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.
|
10485483 |
1999 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Aspirin use and survival after diagnosis of colorectal cancer.
|
19671906 |
2009 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels.
|
11375891 |
2001 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers.
|
18794809 |
2008 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
COX-2 expression and tumor angiogenesis in colorectal cancer.
|
15285012 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Risks of colorectal neoplasms and cardiovascular thromboembolic events after the combined use of selective COX-2 inhibitors and aspirin with 5-year follow-up: a meta-analysis.
|
30656820 |
2019 |
|
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.
|
10945606 |
2000 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
[Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer].
|
12600292 |
2003 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis.
|
16474989 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
|
16818642 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms.
|
10204802 |
1999 |