|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.
|
12771929 |
2003 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells.
|
12664576 |
2002 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The cyclooxygenase-2 (COX-2) gene encodes an inducible enzyme that converts arachidonic acid to prostaglandins and is up-regulated in colorectal neoplasms.
|
12414664 |
2002 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of COX-2 and iNOS mRNA expression was observed in 42.2% and 66.7% of the 90 colorectal tumors, respectively.
|
15695237 |
2005 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.
|
15328521 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer.
|
15102673 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers.
|
17594159 |
2007 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells.
|
17604853 |
2007 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis.
|
19016757 |
2008 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
COX-2 overexpression is a frequent, but not universal event in colorectal neoplasms.
|
21158711 |
2011 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
|
11992399 |
2002 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, overexpression of COX-2 was found more frequently in colorectal tumors with lymphatic invasion, regional lymph node metastasis and larger size, although without statistical significance.
|
15075004 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer.
|
12405290 |
2002 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These data suggest that the LDLr is abnormally regulated in some colorectal tumors and may play a role in the up-regulation of cox-2.
|
10471521 |
1999 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, the downstream prostaglandin (PG)-PG receptor pathway involved in these effects is poorly characterized.We studied the PG-pathway in gene expression databases and we found that PTGS2 (prostaglandin G/H synthase and cyclooxygenase) and PTGES (prostaglandin E synthase) are co-expressed in human colorectal tumors.
|
26498686 |
2015 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclooxygenase 2 (COX-2) is overexpressed frequently in aerodigestive tumors, especially in colorectal tumors.
|
15300574 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We analyzed and compared expression of the inducible COX-2 isoform in colorectal neoplasms from patients with hereditary nonpolyposis colorectal cancer (HNPCC), familial adenomatous polyposis (FAP), and sporadic CRC.
|
10419916 |
1999 |
|
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer.
|
12727794 |
2003 |