|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings establish UPF1 as a potential therapeutic target for HCC patients.
|
28554132 |
2017 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
The results of the present study revealed that UPF1 was significantly downregulated in an HCC cell line.
|
30628676 |
2019 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
In clinical samples of HCC, miR-1468 inversely correlated with the levels of CITED2 and UPF1, which were confirmed to be down-regulated in HCC.
|
29510736 |
2018 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Functionally, UPF1 regulated HCC tumorigenesis both in vitro and in vivo.
|
26759305 |
2016 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma.
|
27702662 |
2016 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion.
|
31040354 |
2019 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings showed that SNAI3-AS1 promotes the progression of HCC by regulating the UPF1 and activating TGF-β/Smad pathway.
|
31264769 |
2019 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The study is the first to prove that the UPF1-Linc-00313-miR-342-3p/miR-485-5p-Zic4-SHCBP1 pathway forms a positive-feedback loop and regulates the biological behaviors of U87 and U251 cells, which might provide a new therapeutic target for glioma.
|
31427569 |
2019 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
UPF1 was conversely downregulated in glioma patients.
|
31696483 |
2019 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Finally, rescue experiments were conducted to ascertain the involvement of CYTOR in UPF1-regulated progression of glioma.
|
31799670 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A novel lncRNA NR4A1AS up-regulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer.
|
31253658 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The impact of NMD activity was also investigated in primary MSI CRCs by quantifying the expression of several mRNAs relative to their mutational status and to endogenous UPF1 and UPF2 expression.
|
18612427 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This work helps validate UPF1 as a novel therapeutic for ALS and other TDP-43-related diseases and may implicate UPF1 and NMD involvement in the underlying disease mechanisms.
|
25354681 |
2015 |
|
Ataxia Telangiectasia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.
|
16086026 |
2005 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data highlight a new, neuronal role for UPF1, distinct from its RNA decay functions, in regulating transport and/or translation of mRNAs that are critical for synaptic plasticity.<b>SIGNIFICANCE STATEMENT</b> The elongation and/or termination steps of mRNA translation are emerging as important control points in mGluR-LTD, a form of synaptic plasticity that is compromised in a severe monogenic form of autism, Fragile X Syndrome.
|
28821679 |
2017 |
|
Choroideremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no correlation between CHM mRNA expression and genotype, phenotype or UPF1 transcript levels.
|
30689859 |
2019 |
|
Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UPF1 expression was detected by qRT-PCR, western blotting, and immunohistochemistry in dextran sulfate sodium-induced colitis in mice.
|
29959727 |
2018 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study aimed to validate the underlying mechanism of UPF1 in UC.
|
29959727 |
2018 |
|
Epilepsy, Temporal Lobe
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upf1 protein levels were also higher in resected hippocampus from patients with intractable temporal lobe epilepsy.
|
28128343 |
2017 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and qRT-PCR analyses were used to detect the expression levels of UPF1 and MALAT1 in gastric cancer and adjacent normal tissues.
|
28942451 |
2017 |
|
Microcephaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We propose that ZIKV, via the capsid protein, has evolved a strategy to lower UPF1 levels and dampen antiviral activities of NMD, which in turn contributes to neuropathology <i>in vivo</i><b>IMPORTANCE</b> Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly.
|
30401782 |
2018 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Key proteins, including cluster of differentiation (CD)31 (platelet endothelial cell adhesion molecule‑1), Vimentin, CD44, PCNA, Ki‑67, N‑Cadherin, Survivin, P53, Met and retinoblastoma exhibited a significant association with UPF1.
|
30628676 |
2019 |
|
Status Epilepticus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunoprecipitation of Upf1-bound RNA from the cytoplasmic and synaptosomal compartments followed by RNA sequencing identified unique populations of NMD-associated transcripts and altered levels after status epilepticus, including known substrates such as Arc as well as novel targets including Inhba and Npas4.
|
28128343 |
2017 |
|
Hallopeau-Siemens Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Amlexanox increased COL7A1 transcript and the phosphorylation of UPF-1, an RNA helicase associated with nonsense-mediated mRNA decay, suggesting that amlexanox inhibits nonsense-mediated mRNA decay in cells from patients with RDEB that respond to read-through treatment.
|
28549954 |
2017 |