|
Choroideremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no correlation between CHM mRNA expression and genotype, phenotype or UPF1 transcript levels.
|
30689859 |
2019 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Key proteins, including cluster of differentiation (CD)31 (platelet endothelial cell adhesion molecule‑1), Vimentin, CD44, PCNA, Ki‑67, N‑Cadherin, Survivin, P53, Met and retinoblastoma exhibited a significant association with UPF1.
|
30628676 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A novel lncRNA NR4A1AS up-regulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer.
|
31253658 |
2019 |
|
Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UPF1 expression was detected by qRT-PCR, western blotting, and immunohistochemistry in dextran sulfate sodium-induced colitis in mice.
|
29959727 |
2018 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study aimed to validate the underlying mechanism of UPF1 in UC.
|
29959727 |
2018 |
|
Microcephaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We propose that ZIKV, via the capsid protein, has evolved a strategy to lower UPF1 levels and dampen antiviral activities of NMD, which in turn contributes to neuropathology <i>in vivo</i><b>IMPORTANCE</b> Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly.
|
30401782 |
2018 |
|
Thalassemia
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We developed a human cellular model of the β<sup>0</sup>39 thalassemia mutation with UPF-1 suppressed and showing a partial NMD suppression.
|
29764417 |
2018 |
|
Zika Virus Infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We propose that ZIKV, via the capsid protein, has evolved a strategy to lower UPF1 levels and dampen antiviral activities of NMD, which in turn contributes to neuropathology <i>in vivo</i><b>IMPORTANCE</b> Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly.
|
30401782 |
2018 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data highlight a new, neuronal role for UPF1, distinct from its RNA decay functions, in regulating transport and/or translation of mRNAs that are critical for synaptic plasticity.<b>SIGNIFICANCE STATEMENT</b> The elongation and/or termination steps of mRNA translation are emerging as important control points in mGluR-LTD, a form of synaptic plasticity that is compromised in a severe monogenic form of autism, Fragile X Syndrome.
|
28821679 |
2017 |
|
Epilepsy, Temporal Lobe
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upf1 protein levels were also higher in resected hippocampus from patients with intractable temporal lobe epilepsy.
|
28128343 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and qRT-PCR analyses were used to detect the expression levels of UPF1 and MALAT1 in gastric cancer and adjacent normal tissues.
|
28942451 |
2017 |
|
Status Epilepticus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunoprecipitation of Upf1-bound RNA from the cytoplasmic and synaptosomal compartments followed by RNA sequencing identified unique populations of NMD-associated transcripts and altered levels after status epilepticus, including known substrates such as Arc as well as novel targets including Inhba and Npas4.
|
28128343 |
2017 |
|
Hallopeau-Siemens Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Amlexanox increased COL7A1 transcript and the phosphorylation of UPF-1, an RNA helicase associated with nonsense-mediated mRNA decay, suggesting that amlexanox inhibits nonsense-mediated mRNA decay in cells from patients with RDEB that respond to read-through treatment.
|
28549954 |
2017 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and qRT-PCR analyses were used to detect the expression levels of UPF1 and MALAT1 in gastric cancer and adjacent normal tissues.
|
28942451 |
2017 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this investigation we studied the role of Up-frameshift 1 (UPF1) in the tumorigenesis of HCC.
|
26759305 |
2016 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This work helps validate UPF1 as a novel therapeutic for ALS and other TDP-43-related diseases and may implicate UPF1 and NMD involvement in the underlying disease mechanisms.
|
25354681 |
2015 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the association between NMD complex component UPF1/SMG1 and premature termination codons containing mRNA (PTC-mRNA).
|
25520033 |
2014 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the association between NMD complex component UPF1/SMG1 and premature termination codons containing mRNA (PTC-mRNA).
|
25520033 |
2014 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the association between NMD complex component UPF1/SMG1 and premature termination codons containing mRNA (PTC-mRNA).
|
25520033 |
2014 |
|
Pancreatic Adenosquamous Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
UPF1 mutations are, to our knowledge, the first known unique molecular signatures of pancreatic ASC.
|
24859531 |
2014 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Additionally, the predominant nuclear localization of UPF1 in normal glandular cells and low grade tumors was switched to a more cytoplasmic pattern in carcinomas with Gleason score >7.
|
23881279 |
2013 |