|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In silico screening of UPF1 stability change as a function over 41 cancer mutations has identified five variants with significant effects: K164R, R253W, T499M, E637K, and E833K.
|
31718065 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In silico screening of UPF1 stability change as a function over 41 cancer mutations has identified five variants with significant effects: K164R, R253W, T499M, E637K, and E833K.
|
31718065 |
2019 |
|
Thalassemia
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We developed a human cellular model of the β<sup>0</sup>39 thalassemia mutation with UPF-1 suppressed and showing a partial NMD suppression.
|
29764417 |
2018 |
|
Pancreatic Adenosquamous Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
UPF1 mutations are, to our knowledge, the first known unique molecular signatures of pancreatic ASC.
|
24859531 |
2014 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Upregulation of SNHG6 expression induced RKO and HCT116 cell proliferation as well as RKO cell metastasis, while downregulation of SNHG6 expression supressed the proliferation and metastasis of RKO cells and tumor growth <i>in vivo.</i> UPF1 was upregulated and ZEB1 was decreased when SNHG6 knockdown, regulating the TGF-β/Smad pathway and inducing EMT respectively.
|
30662328 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Our findings revealed that UPF1 is a potential tumor suppressive gene and may be a potential therapeutic target for HCC.
|
26759305 |
2016 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Additionally, the predominant nuclear localization of UPF1 in normal glandular cells and low grade tumors was switched to a more cytoplasmic pattern in carcinomas with Gleason score >7.
|
23881279 |
2013 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In the present study, the role of Up‑frameshift 1 (UPF1), a potential tumor suppressor, was investigated in the HCC cell lines.
|
30628676 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Collectively, UPF1 functions as a tumor suppressor by preventing cancer stem cell (CSC)-like characteristics, inhibiting EMT process and enhancing chemotherapeutic sensitivity via inhibiting ABCC2 expression in HCC cells.
|
28554132 |
2017 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings establish UPF1 as a potential therapeutic target for HCC patients.
|
28554132 |
2017 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Functionally, UPF1 regulated HCC tumorigenesis both in vitro and in vivo.
|
26759305 |
2016 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma.
|
27702662 |
2016 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion.
|
31040354 |
2019 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings showed that SNAI3-AS1 promotes the progression of HCC by regulating the UPF1 and activating TGF-β/Smad pathway.
|
31264769 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Our results reveal that Linc-ASEN prevents cellular senescence by reducing the transcription and stability of p21 mRNA in concert with UPF1, and suggest that Linc-ASEN might be a potential therapeutic target in processes influenced by senescence, including cancer.
|
31819156 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Collectively, UPF1 functions as a tumor suppressor by preventing cancer stem cell (CSC)-like characteristics, inhibiting EMT process and enhancing chemotherapeutic sensitivity via inhibiting ABCC2 expression in HCC cells.
|
28554132 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Our results reveal that Linc-ASEN prevents cellular senescence by reducing the transcription and stability of p21 mRNA in concert with UPF1, and suggest that Linc-ASEN might be a potential therapeutic target in processes influenced by senescence, including cancer.
|
31819156 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Collectively, UPF1 functions as a tumor suppressor by preventing cancer stem cell (CSC)-like characteristics, inhibiting EMT process and enhancing chemotherapeutic sensitivity via inhibiting ABCC2 expression in HCC cells.
|
28554132 |
2017 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The study is the first to prove that the UPF1-Linc-00313-miR-342-3p/miR-485-5p-Zic4-SHCBP1 pathway forms a positive-feedback loop and regulates the biological behaviors of U87 and U251 cells, which might provide a new therapeutic target for glioma.
|
31427569 |
2019 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Finally, rescue experiments were conducted to ascertain the involvement of CYTOR in UPF1-regulated progression of glioma.
|
31799670 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Collectively, PKP1/3-associated RBPs FXR1 and UPF1 may have a functional role in prostate cancer progression and metastasis and highlight the potential importance of posttranscriptional regulation of gene expression and nonsense-mediated decay in cancer.
|
23881279 |
2013 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MTT, cell cycle, apoptosis and transwell assays were performed to examine the effects of UPF1 on cell cycle progression, cell proliferation, apoptosis, migration and invasion.
|
28942451 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion.
|
31040354 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This work helps validate UPF1 as a novel therapeutic for ALS and other TDP-43-related diseases and may implicate UPF1 and NMD involvement in the underlying disease mechanisms.
|
25354681 |
2015 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data highlight a new, neuronal role for UPF1, distinct from its RNA decay functions, in regulating transport and/or translation of mRNAs that are critical for synaptic plasticity.<b>SIGNIFICANCE STATEMENT</b> The elongation and/or termination steps of mRNA translation are emerging as important control points in mGluR-LTD, a form of synaptic plasticity that is compromised in a severe monogenic form of autism, Fragile X Syndrome.
|
28821679 |
2017 |