|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
To test this hypothesis, we sequenced the IIp45 gene in 59 diffuse glioma samples of different grades and histologic subtypes and identified a possible point mutation or a rare polymorphism in only one sample (1.7%), suggesting that IIp45 is not a classic tumor suppressor gene such as p53.
|
15867349 |
2005 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Twenty-six percent (37/142) of tumors were shown to have LOH at the MIIP locus by MS and SNP markers.
|
25873164 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterogeneity (LOH) of the MIIP gene was determined using single-nucleotide polymorphism (SNP) and microsatellite (MS) markers in 149 breast carcinomas and the corresponding normal lymphocytes.
|
25873164 |
2015 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our study further emphasized the tumor suppressive role of MIIP and illustrated a novel mechanism.
|
31092266 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC.
|
27741356 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have characterized the migration and invasion inhibitory protein (MIIP) as a novel putative tumor-suppressor gene that regulates cell migration and invasion as well as the mitotic checkpoint.
|
25873164 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
We deleted one copy of the MIIP gene in HCT116 CRC cells using zinc finger nuclease technology and demonstrated that MIIP haploinsufficiency resulted in increased colony formation and cell migration and invasion, which was consistent with the results from siRNA-mediated MIIP knockdown in two CRC cell lines (p < 0.05 for all).
|
27741356 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The gene encoding migration and invasion inhibitory protein (MIIP), located on 1p36.22, is a potential tumour suppressor gene in glioma.
|
27741356 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
As a newly identified tumor suppressor, MIIP exerts its role in various types of cancer but has not been investigated in PCa.
|
31092266 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC.
|
27741356 |
2017 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.
|
27741356 |
2017 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MIIP is associated with cancer progression in various cancers.
|
30588008 |
2018 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Correction to: MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling.
|
31639006 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer.
|
29343850 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Correction to: MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling.
|
31639006 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
As a newly identified tumor suppressor, MIIP exerts its role in various types of cancer but has not been investigated in PCa.
|
31092266 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |