|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The IIp45 protein was not expressed in some GBMs.
|
14617774 |
2003 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
To test this hypothesis, we sequenced the IIp45 gene in 59 diffuse glioma samples of different grades and histologic subtypes and identified a possible point mutation or a rare polymorphism in only one sample (1.7%), suggesting that IIp45 is not a classic tumor suppressor gene such as p53.
|
15867349 |
2005 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
To test this hypothesis, we sequenced the IIp45 gene in 59 diffuse glioma samples of different grades and histologic subtypes and identified a possible point mutation or a rare polymorphism in only one sample (1.7%), suggesting that IIp45 is not a classic tumor suppressor gene such as p53.
|
15867349 |
2005 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that the MIIP protein was reduced or undetectable in some tissue samples obtained from patients with glioblastoma.
|
20418911 |
2010 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that the MIIP protein was reduced or undetectable in some tissue samples obtained from patients with glioblastoma.
|
20418911 |
2010 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that the MIIP protein was reduced or undetectable in some tissue samples obtained from patients with glioblastoma.
|
20418911 |
2010 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that the MIIP protein was reduced or undetectable in some tissue samples obtained from patients with glioblastoma.
|
20418911 |
2010 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Twenty-six percent (37/142) of tumors were shown to have LOH at the MIIP locus by MS and SNP markers.
|
25873164 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have characterized the migration and invasion inhibitory protein (MIIP) as a novel putative tumor-suppressor gene that regulates cell migration and invasion as well as the mitotic checkpoint.
|
25873164 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MIIP gene mRNA and protein expression was assessed in 86 matched breast cancer and adjacent normal tissues.
|
25873164 |
2015 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterogeneity (LOH) of the MIIP gene was determined using single-nucleotide polymorphism (SNP) and microsatellite (MS) markers in 149 breast carcinomas and the corresponding normal lymphocytes.
|
25873164 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in non-small cell lung cancer.
|
26824318 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the higher MIIP protein expression predicts a better overall survival of Stage IA-IIIA lung adenocarcinoma patients who underwent radical surgery.
|
26824318 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC.
|
27741356 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
We deleted one copy of the MIIP gene in HCT116 CRC cells using zinc finger nuclease technology and demonstrated that MIIP haploinsufficiency resulted in increased colony formation and cell migration and invasion, which was consistent with the results from siRNA-mediated MIIP knockdown in two CRC cell lines (p < 0.05 for all).
|
27741356 |
2017 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The gene encoding migration and invasion inhibitory protein (MIIP), located on 1p36.22, is a potential tumour suppressor gene in glioma.
|
27741356 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Analysis of The Cancer Genome Atlas (TCGA) data showed that decreased MIIP expression was significantly associated with MIIP hemizygous deletion (p = 0.0005), which was detected in 27.7% (52/188) of CRC cases, and associated with lymph node and distant metastasis (p < 0.05 for both).
|
27741356 |
2017 |