|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our study further emphasized the tumor suppressive role of MIIP and illustrated a novel mechanism.
|
31092266 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Transwell and wound-healing assays were used to detect cell invasion and migration after MIIP overexpression.
|
31078343 |
2019 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Moreover, the dysregulated miR-646 and MIIP expression was correlated with advanced tumor stage, lymphatic invasion, metastasis and shorter overall survival in PC patients.
|
29343850 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Ectopic expression of MIIP in GC cell lines BGC823 and HGC27 induced G<sub>0</sub>/G<sub>1</sub> cell cycle arrest and inhibited cell proliferation, colony formation, migration and invasion in vitro, as well as the growth of GC xenografts and metastasis of tumors in vivo.
|
30588008 |
2018 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
MIIP is downregulated in gastric cancer and its forced expression inhibits proliferation and invasion of gastric cancer cells in vitro and in vivo.
|
30588008 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC.
|
27741356 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
We deleted one copy of the MIIP gene in HCT116 CRC cells using zinc finger nuclease technology and demonstrated that MIIP haploinsufficiency resulted in increased colony formation and cell migration and invasion, which was consistent with the results from siRNA-mediated MIIP knockdown in two CRC cell lines (p < 0.05 for all).
|
27741356 |
2017 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Twenty-six percent (37/142) of tumors were shown to have LOH at the MIIP locus by MS and SNP markers.
|
25873164 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have characterized the migration and invasion inhibitory protein (MIIP) as a novel putative tumor-suppressor gene that regulates cell migration and invasion as well as the mitotic checkpoint.
|
25873164 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitory protein MIIP is an inhibitor of cancer cell migration and invasion that inhibits breast tumorigenesis.
|
20103646 |
2010 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
To test this hypothesis, we sequenced the IIp45 gene in 59 diffuse glioma samples of different grades and histologic subtypes and identified a possible point mutation or a rare polymorphism in only one sample (1.7%), suggesting that IIp45 is not a classic tumor suppressor gene such as p53.
|
15867349 |
2005 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MTT assay and colony formation assay were used to detect cell viability of breast cancer cells after MIIP overexpression.
|
31078343 |
2019 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MTT assay and colony formation assay were used to detect cell viability of breast cancer cells after MIIP overexpression.
|
31078343 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic expression of MIIP in GC cell lines BGC823 and HGC27 induced G<sub>0</sub>/G<sub>1</sub> cell cycle arrest and inhibited cell proliferation, colony formation, migration and invasion in vitro, as well as the growth of GC xenografts and metastasis of tumors in vivo.
|
30588008 |
2018 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The gene encoding migration and invasion inhibitory protein (MIIP), located on 1p36.22, is a potential tumour suppressor gene in glioma.
|
27741356 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA-this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.
|
29038521 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Analysis of The Cancer Genome Atlas (TCGA) data showed that decreased MIIP expression was significantly associated with MIIP hemizygous deletion (p = 0.0005), which was detected in 27.7% (52/188) of CRC cases, and associated with lymph node and distant metastasis (p < 0.05 for both).
|
27741356 |
2017 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MIIP gene mRNA and protein expression was assessed in 86 matched breast cancer and adjacent normal tissues.
|
25873164 |
2015 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterogeneity (LOH) of the MIIP gene was determined using single-nucleotide polymorphism (SNP) and microsatellite (MS) markers in 149 breast carcinomas and the corresponding normal lymphocytes.
|
25873164 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The migration and invasion inhibitor protein (MIIP, also known as IIp45) was discovered as a negative regulator of cell migration and invasion in glioma.
|
20418911 |
2010 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
|
20103646 |
2010 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
To test this hypothesis, we sequenced the IIp45 gene in 59 diffuse glioma samples of different grades and histologic subtypes and identified a possible point mutation or a rare polymorphism in only one sample (1.7%), suggesting that IIp45 is not a classic tumor suppressor gene such as p53.
|
15867349 |
2005 |