|
Parkinson Disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal hydrolase as rare causes of autosomal dominant PD and mutations in parkin as a cause of autosomal recessive PD.
|
12067634 |
2002 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Transgenic (TG) mice expressing human chorionic gonadotropin (hCG) beta-subunit under the ubiquitin C promoter, presenting with a moderately elevated level of LH/hCG bioactivity develop multiple neoplasms secondary to the endocrine abnormalities, including mammary gland tumors after the age of 9 months.
|
17510243 |
2007 |
|
Tumor Cell Invasion
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
HCC cell migration and invasion together with the interaction between PRDX1 and ubiquitin C-terminal hydrolase 37 (UCH37) were studied in vitro.
|
29377617 |
2018 |
|
Bladder neck obstruction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Transgenic (Tg) male mice overexpressing aromatase (Cyp19a1) under the ubiquitin C promoter in the estrogen-susceptible C57Bl/6J genetic background (AROM+/6J) developed inguinal hernia by 2 months and severe BOO by 9 to 10 months, with 100% penetrance.
|
21356374 |
2011 |
|
Epidermolysis Bullosa
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Type XVI collagen (COL16A1), G0/G1 switch 2 (G0S2), fibronectin (FN1), ribosomal protein S27A (RPS27A) and low density lipoprotein receptor (LDLR) were shown to exhibit corresponding changes in gene expression in all three EB subtypes.
|
22716248 |
2012 |
|
Hernia, Inguinal
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Transgenic (Tg) male mice overexpressing aromatase (Cyp19a1) under the ubiquitin C promoter in the estrogen-susceptible C57Bl/6J genetic background (AROM+/6J) developed inguinal hernia by 2 months and severe BOO by 9 to 10 months, with 100% penetrance.
|
21356374 |
2011 |
|
Retinoblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, ubiquitin C (UBC) and six additional TSGs including the adenomatous polyposis coli gene (APC), death associated protein kinase gene (DAPK), pleiomorphic adenoma gene-like 1 (PLAGL1), retinoblastoma susceptibility gene (RB1), a gene encoding an apoptosis-associated speck-like protein (PYCARD/ASC) and tumor protein 63 (TP63), which had close interactions with the 15 TSGs, are potential drug resistance-related genes in ovarian cancer.
|
23660957 |
2013 |
|
Anemia, Diamond-Blackfan
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Overexpression of RPS27a contributes to enhanced chemoresistance of CML cells to imatinib by the transactivated STAT3.
|
26942564 |
2016 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been linked to Parkinson's disease (PD) and other neurodegenerative diseases.
|
21251915 |
2011 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease.
|
29535397 |
2018 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD).
|
28300150 |
2017 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Genetic studies have implicated the neuronal ubiquitin C-terminal hydrolase (UCH) protein UCH-L1 in Parkinson's disease (PD) pathogenesis.
|
22076440 |
2012 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14), resulting in accumulation of polyubiquitin. b-AP15 induced tumor cell apoptosis that was insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2.
|
22057347 |
2011 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The network analysis revealed that the candidate genes identified in AR chickens play roles in networks centered to ubiquitin C (<i>UBC</i>), phosphoinositide 3-kinases (<i>PI3K</i>), and nuclear factor kappa B (<i>NF-kB</i>) complexes suggesting that the tumor regression property in AR chickens might be associated with ubiquitylation, <i>PI3K</i>, and <i>NF-kB</i> signaling pathways.
|
30347774 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Ubiquitin C-terminal hydrolase deubiquitinase BAP1 is an essential tumor suppressor involved in cell growth control, DNA damage response, and transcriptional regulation.
|
30639226 |
2019 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Three hundred and forty-seven genes associated with autophagy in human pancreatic cancer were concentrated, and a key gene ubiquitin C which is closely related to the occurrence of PNI was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.
|
31114135 |
2019 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition to these two genes, Ubiquitin C (UBC) in head and neck cancer and Transferrin receptor (TFRC) and β-Glucuronidase (GUSB) in pancreatic cancer were identified to be stable as well.
|
28262749 |
2017 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
Three hundred and forty-seven genes associated with autophagy in human pancreatic cancer were concentrated, and a key gene ubiquitin C which is closely related to the occurrence of PNI was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.
|
31114135 |
2019 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition to these two genes, Ubiquitin C (UBC) in head and neck cancer and Transferrin receptor (TFRC) and β-Glucuronidase (GUSB) in pancreatic cancer were identified to be stable as well.
|
28262749 |
2017 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The ubiquitin-specific proteases (USPs), a family member of DUBs mostly involved in the regulation of cellular pathways for PCa development, and the ubiquitin C-terminal hydrolases (UCHs), another family member of DUBs, are responsible for PCa metastasis.
|
31062387 |
2019 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
UBCEP-1 mediated ubiquitin chain elongation may promote prostate carcinoma development by increasing via the proteasome pathway the degradation of proteins which are involved in growth inhibition or apoptosis.
|
15647830 |
2005 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our previous studies demonstrated selected higher expression of a gene encoding ubiquitin-ribosomal protein S27a in poorly differentiated colon carcinoma cell lines.
|
2009061 |
1991 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
RPS27a also enhances LMP1-mediated proliferation and invasion, suggesting that RPS27a interacts with LMP1 and stabilizes it by suppressing proteasome-mediated ubiquitination.
|
28735865 |
2017 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Network analysis reveals new potential roles of ubiquitin C in the pathogenesis of HCC.
|
25247452 |
2015 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study opens up a new window for YB-1-RPS27A axis in HCC.
|
24833360 |
2014 |