|
Anemia, Diamond-Blackfan
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Overexpression of RPS27a contributes to enhanced chemoresistance of CML cells to imatinib by the transactivated STAT3.
|
26942564 |
2016 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease.
|
29535397 |
2018 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD).
|
28300150 |
2017 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Genetic studies have implicated the neuronal ubiquitin C-terminal hydrolase (UCH) protein UCH-L1 in Parkinson's disease (PD) pathogenesis.
|
22076440 |
2012 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been linked to Parkinson's disease (PD) and other neurodegenerative diseases.
|
21251915 |
2011 |
|
Parkinson Disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal hydrolase as rare causes of autosomal dominant PD and mutations in parkin as a cause of autosomal recessive PD.
|
12067634 |
2002 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Ubiquitin C-terminal hydrolase deubiquitinase BAP1 is an essential tumor suppressor involved in cell growth control, DNA damage response, and transcriptional regulation.
|
30639226 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The network analysis revealed that the candidate genes identified in AR chickens play roles in networks centered to ubiquitin C (<i>UBC</i>), phosphoinositide 3-kinases (<i>PI3K</i>), and nuclear factor kappa B (<i>NF-kB</i>) complexes suggesting that the tumor regression property in AR chickens might be associated with ubiquitylation, <i>PI3K</i>, and <i>NF-kB</i> signaling pathways.
|
30347774 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14), resulting in accumulation of polyubiquitin. b-AP15 induced tumor cell apoptosis that was insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2.
|
22057347 |
2011 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Transgenic (TG) mice expressing human chorionic gonadotropin (hCG) beta-subunit under the ubiquitin C promoter, presenting with a moderately elevated level of LH/hCG bioactivity develop multiple neoplasms secondary to the endocrine abnormalities, including mammary gland tumors after the age of 9 months.
|
17510243 |
2007 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Three hundred and forty-seven genes associated with autophagy in human pancreatic cancer were concentrated, and a key gene ubiquitin C which is closely related to the occurrence of PNI was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.
|
31114135 |
2019 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
Three hundred and forty-seven genes associated with autophagy in human pancreatic cancer were concentrated, and a key gene ubiquitin C which is closely related to the occurrence of PNI was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.
|
31114135 |
2019 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The ubiquitin-specific proteases (USPs), a family member of DUBs mostly involved in the regulation of cellular pathways for PCa development, and the ubiquitin C-terminal hydrolases (UCHs), another family member of DUBs, are responsible for PCa metastasis.
|
31062387 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
HCC cell migration and invasion together with the interaction between PRDX1 and ubiquitin C-terminal hydrolase 37 (UCH37) were studied in vitro.
|
29377617 |
2018 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition to these two genes, Ubiquitin C (UBC) in head and neck cancer and Transferrin receptor (TFRC) and β-Glucuronidase (GUSB) in pancreatic cancer were identified to be stable as well.
|
28262749 |
2017 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition to these two genes, Ubiquitin C (UBC) in head and neck cancer and Transferrin receptor (TFRC) and β-Glucuronidase (GUSB) in pancreatic cancer were identified to be stable as well.
|
28262749 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
RPS27a also enhances LMP1-mediated proliferation and invasion, suggesting that RPS27a interacts with LMP1 and stabilizes it by suppressing proteasome-mediated ubiquitination.
|
28735865 |
2017 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Network analysis reveals new potential roles of ubiquitin C in the pathogenesis of HCC.
|
25247452 |
2015 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study opens up a new window for YB-1-RPS27A axis in HCC.
|
24833360 |
2014 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
UBCEP-1 mediated ubiquitin chain elongation may promote prostate carcinoma development by increasing via the proteasome pathway the degradation of proteins which are involved in growth inhibition or apoptosis.
|
15647830 |
2005 |
|
Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The mRNA of several ribosomal proteins, and of another ubiquitin A gene fusion protein, UbA80, with an 80 amino acid extension of ribosomal protein S27a, have been reported to be over-expressed in colon cancer, but not as yet at the protein level.
|
8541345 |
1995 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our previous studies demonstrated selected higher expression of a gene encoding ubiquitin-ribosomal protein S27a in poorly differentiated colon carcinoma cell lines.
|
2009061 |
1991 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the effect of ubiquitin C-terminal hydrolase 1 (UCHL1), an important DUB, on the development of AF induced by angiotensin II (Ang II).
|
31700166 |
2020 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Correlation of ubiquitin C terminal hydrolase and S100β with cognitive deficits in young adults with mild traumatic brain injury.
|
28681747 |
2019 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the value of postictal serum Ubiquitin C-terminal hydrolase (UCHL-1), a neuronal biomarker, and S100-B, a glial biomarker, levels, in differentiate epileptic seizures (ES) form psychogenic attacks.
|
30253122 |
2019 |