|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our previous studies demonstrated selected higher expression of a gene encoding ubiquitin-ribosomal protein S27a in poorly differentiated colon carcinoma cell lines.
|
2009061 |
1991 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ubiquitin-ribosomal protein S27a gene overexpressed in human colorectal carcinoma is an early growth response gene.
|
8385574 |
1993 |
|
Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The mRNA of several ribosomal proteins, and of another ubiquitin A gene fusion protein, UbA80, with an 80 amino acid extension of ribosomal protein S27a, have been reported to be over-expressed in colon cancer, but not as yet at the protein level.
|
8541345 |
1995 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Using rabbit antisera to the ribosomal protein component S27a we demonstrate over-expression of S27a at the protein level in colonic (n = 5), but not gastric (n = 6) carcinomas.
|
8541345 |
1995 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA of several ribosomal proteins, and of another ubiquitin A gene fusion protein, UbA80, with an 80 amino acid extension of ribosomal protein S27a, have been reported to be over-expressed in colon cancer, but not as yet at the protein level.
|
8541345 |
1995 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.
|
8845848 |
1996 |
|
Parkinson Disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal hydrolase as rare causes of autosomal dominant PD and mutations in parkin as a cause of autosomal recessive PD.
|
12067634 |
2002 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
UBCEP-1 mediated ubiquitin chain elongation may promote prostate carcinoma development by increasing via the proteasome pathway the degradation of proteins which are involved in growth inhibition or apoptosis.
|
15647830 |
2005 |
|
Cachexia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Gene expression of ubiquitin C and proteasome subunits C2, C3, and C9 was not changed in the uremic animals, suggesting that other pathways are involved in this model of nonacidotic uremic cachexia.
|
15931394 |
2005 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
A novel component of the ubiquitin pathway, ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer.
|
15647830 |
2005 |
|
Seminoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ubiquitin C (protein degradation) was down-regulated, GAPDH (carbohydrate metabolism), beta-actin (cytoskeleton), 18S rRNA (ribosome) and PBGD (porphyrin metabolism) were up-regulated in seminoma.
|
15823405 |
2005 |
|
Lewy Body Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.
|
16380264 |
2006 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Transgenic (TG) mice expressing human chorionic gonadotropin (hCG) beta-subunit under the ubiquitin C promoter, presenting with a moderately elevated level of LH/hCG bioactivity develop multiple neoplasms secondary to the endocrine abnormalities, including mammary gland tumors after the age of 9 months.
|
17510243 |
2007 |
|
Sandhoff Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These studies, confirmed by biochemical experiments, demonstrated that lysosomal storage is associated with downregulation of ubiquitin C-terminal hydrolase, UCH-L1 in the cells of eight different lysosomal disorders, as well as in the brain of a mouse model of Sandhoff disease.
|
16888648 |
2007 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We tested five reference genes for stability on our sample set and using the three most stable ones (YWHAZ, ubiquitin c, and HPRT) obtained rather small intra-group variance for cyclin D1 expression in most lymphomas.
|
20727381 |
2010 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been linked to Parkinson's disease (PD) and other neurodegenerative diseases.
|
21251915 |
2011 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14), resulting in accumulation of polyubiquitin. b-AP15 induced tumor cell apoptosis that was insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2.
|
22057347 |
2011 |
|
Bladder neck obstruction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Transgenic (Tg) male mice overexpressing aromatase (Cyp19a1) under the ubiquitin C promoter in the estrogen-susceptible C57Bl/6J genetic background (AROM+/6J) developed inguinal hernia by 2 months and severe BOO by 9 to 10 months, with 100% penetrance.
|
21356374 |
2011 |
|
Hernia, Inguinal
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Transgenic (Tg) male mice overexpressing aromatase (Cyp19a1) under the ubiquitin C promoter in the estrogen-susceptible C57Bl/6J genetic background (AROM+/6J) developed inguinal hernia by 2 months and severe BOO by 9 to 10 months, with 100% penetrance.
|
21356374 |
2011 |
|
Rous Sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The commonly used cytomegalovirus major immediate early (CMV) promoter led to high-level swelling that was independent of transgene expression, while the Rous sarcoma virus and human ubiquitin C promoters led to intermediate levels of swelling and the Ad E1A promoter or no promoter led to equally low levels of swelling.
|
21255815 |
2011 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been linked to Parkinson's disease (PD) and other neurodegenerative diseases.
|
21251915 |
2011 |
|
Parkinson Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Genetic studies have implicated the neuronal ubiquitin C-terminal hydrolase (UCH) protein UCH-L1 in Parkinson's disease (PD) pathogenesis.
|
22076440 |
2012 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA for ER (ESR1) and Ubiquitin C (UbC) were visualized using RNAscope probes and levels were quantified by quantitative in situ hybridization (qISH) on two Yale breast cancer cohorts on tissue microarrays.
|
22606272 |
2012 |
|
Epidermolysis Bullosa
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Type XVI collagen (COL16A1), G0/G1 switch 2 (G0S2), fibronectin (FN1), ribosomal protein S27A (RPS27A) and low density lipoprotein receptor (LDLR) were shown to exhibit corresponding changes in gene expression in all three EB subtypes.
|
22716248 |
2012 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA for ER (ESR1) and Ubiquitin C (UbC) were visualized using RNAscope probes and levels were quantified by quantitative in situ hybridization (qISH) on two Yale breast cancer cohorts on tissue microarrays.
|
22606272 |
2012 |