Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The mean of BDNF from FM compared to MDD was 35.70% higher [49.82 (16.31) vs. 14.12 (8.86)].
|
31105542 |
2019 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
L-3'-UTRs containing BDNF messenger RNAs, which migrate to distal dendrites of pyramidal neurons, are selectively reduced, and their expression was highly correlated with SST expression in the prefrontal cortex of subjects with MDD.
|
30449530 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, findings of this study suggest an involvement of peripheral as well as additional - possibly brain-derived - mechanisms explaining exercise-related BDNF release in MDD.
|
30583245 |
2019 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Acute and subsequent continuation electroconvulsive therapy elevates serum BDNF levels in patients with major depression.
|
31000384 |
2019 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this review, we will provide recent advances on glial dysfunctions, the role of inflammatory cytokines, transcription factors, and brain derived neurotrophic factor underlying the pathophysiology of major depressive disorder.
|
31601403 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We evaluated the effects and association with BDNF of rhythmic LFMS in the treatment of major depressive disorder (MDD).
|
29460712 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
BDNF exon IV and p11 promoter methylation was not associated with test performance.<b>Conclusions:</b> Our results corroborate a concomitant amelioration of executive dysfunctions with successful antidepressant therapy and support a role of BDNF in the neural mechanisms underlying the normalisation of executive dysfunctions in MDD.<b>ClinicalTrials.gov number:</b> NCT00974155; EudraCT: 2008-008280-96.
|
29334322 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Numerous studies in humans and rodents have implicated brain-derived neurotrophic factor (BDNF) in MDD pathology, as a genetic risk factor and a factor regulated by stress.
|
30548775 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The contribution of 7 polymorphisms from 5 genes (APOE, HSPA1A, SLC6A4, HTR2A, and BDNF) related to risk of MDD or AD development was analyzed.
|
29703883 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the serum BDNF and GDNF levels before and after 12 weeks of antidepressant treatment in MDD outpatients.
|
29945425 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
BDNF and miRNA in MDD had been investigated widely in the recent years, but the relationships between miRNAs and antidepressants were less studied.
|
30269040 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Such an association would be consistent with low brain-derived neurotrophic factor mediating the effect of early life adversity on adulthood suicide and major depressive disorder.
|
29432620 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers.
|
29778546 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that SA did not interfere in the serum levels of BDNF, indicating that this neurotrophin may be related to the diagnosis of MDD and not to suicide attempt.
|
28942954 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We recently provided preliminary evidence in a small study that patients with major depressive disorder (MDD) with a hypomethylation of the CpG-87 site of the promoter IV region of the brain-derived neurotrophic factor (BDNF) gene are less likely to benefit from antidepressants.
|
30459647 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study supported a role of BDNF and VEGFA variants in MDD therapeutic response.
|
29725086 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we report serum (sBDNF) and plasma (pBDNF) levels from a randomized controlled, adjunctive, sequential parallel comparison design trial of riluzole in MDD.
|
30153634 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some studies reported an association between the Val66Met polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene with MDD and peripheral BDNF levels.
|
28656803 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The development of MDD in midlife women may be associated with a systemic cascade of pro-oxidative and pro-inflammatory events including increased HSP70, 3-nitrotyrosine, protein carbonyl, and lipid peroxidation and decreased BDNF.
|
28550365 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Follow-up analyses assessed corresponding BDNF genotype effects on resting-state functional connectivity (n = 186) and the association between BDNF genotype and major depressive disorder (MDD) (n = 2749).
|
28387866 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We searched five electronic databases (PubMed, PsycINFO, CHINAL, Cochran Library, and Japanese Central Review of Medicine) for interventional studies released prior to 24 October 2017, examining the effects of physical exercise on BDNF in patients with MDD that compared the experimental group with an MDD control group.
|
29930221 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed.
|
29414128 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Similarities in BDNF expression between animal models of stress and those in MDD will be highlighted.
|
29243873 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The retrospective assessment of a lifetime history of depression may be subject to information bias and this study only establishes a cross-sectional association between lifetime history of MDD and lower levels of BDNF in patients with dementia.
|
30125821 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This meta-analysis did not find evidence that a chronic aerobic exercise intervention increases resting concentrations of BDNF in the blood of MDD patients; however, there is a lack of studies in this area making it difficult to reach a definitive conclusion.
|
30219561 |
2018 |