|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relative transcriptional activities of SAA1 promoters polymorphic at position -13(T/C): potential association between increased transcription and amyloidosis.
|
16076608 |
2005 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the gamma/gamma genotype and gamma alleles at the SAA1 locus were significantly higher in the amyloidosis population than in the early RA population (34.9% versus 7.8%, and 58.1% versus 33.8%, chi2 test P=0.0001).
|
10543406 |
1999 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
M694V homozygocity, male gender and the alpha/alpha genotype of serum amyloid A1 gene are the currently established risk factors for development of amyloidosis.
|
16283319 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest a protective effect of the SAA1 beta and gamma alleles on the development of amyloidosis and show the absence of a MICA modifying effect on amyloidosis development.
|
15018633 |
2004 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1 alpha/alpha genotype is a risk factor for AA type amyloidosis in Caucasoid populations and more studies are needed to investigate why the gamma/gamma genotype is associated with AA type amyloidosis in Japan.
|
16736418 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis for amyloidosis corrected risk revealed a 1.2 times increase in M694V/M694V, a 2.4 times increase in SAA1 alpha/alpha genotypes and a 2.5 times increase when both are together.
|
16118480 |
2005 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population.
|
15170927 |
2004 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Caucasians, the -13T allele had a stronger association with amyloidosis than did the SAA1.1 allele.
|
12762135 |
2003 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD.
|
17039260 |
2007 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that the SAA1 rs12218 polymorphism was significantly more prevalent in ankylosing spondylitis patients with amyloidosis.
|
26300108 |
2015 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to determine the effect of SAA1 -13T/C in FMF patients with and without amyloidosis.
|
16874691 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analyzed the contribution of genotypes at the MEFV and SAA1 loci to disease severity and to the development of amyloidosis, and further defined the factors affecting the clinical profile of FMF.
|
12687559 |
2003 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In Caucasians, the -13T allele had a stronger association with amyloidosis than did the SAA1.1 allele.
|
12762135 |
2003 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk of amyloidosis is increased in male FMF patients and in patients bearing polymorphism a/a in the SAA1 gene.
|
12832747 |
2003 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the study emphasizes the importance of SAA gene structure in determining susceptibility to amyloidosis.
|
3456645 |
1986 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD.
|
17039260 |
2007 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine if SAA concentrations and SAA1 gene polymorphisms could explain the virtual absence of amyloidosis in HIDS patients.
|
16011988 |
2005 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1 α allele is strongly associated with amyloidosis in FMF patients.
|
27791951 |
2017 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorphisms (SNPs), C-13T, C2995T, and C3010T, in the SAA gene.
|
17039310 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Serum amyloid A1 and tumor necrosis factor-alpha alleles in Turkish familial Mediterranean fever patients with and without amyloidosis.
|
12762136 |
2003 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis.
|
17968686 |
2007 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1-alpha/alpha genotype was associated with an increased risk of amyloidosis.
|
12836090 |
2003 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Treatment with weekly rilonacept provided marked and lasting improvement in the clinical signs and symptoms of CAPS, and normalized the levels of SAA from those associated with risk of developing amyloidosis.
|
18668535 |
2008 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human SAA and its NH<sub>2</sub>-terminal part have been studied extensively in the context of amyloidosis.
|
29915572 |
2018 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cell culture model of amyloid formation from serum amyloid A1 (SAA1) protein remodels crucial features of AA amyloid deposit formation in vivo.
|
30739503 |
2019 |