Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum SAA levels, plasma cytokines, glomerular filtration rate and serum amyloid P scanning were monitored.
|
15316120 |
2004 |
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In Caucasian patients with JCA, the presence of the homozygous SAA1 alpha genotype indicates high risk of amyloidosis and should encourage early and aggressive anti-inflammatory therapy to keep circulating SAA levels as low as possible.
|
10036584 |
1998 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human SAA and its NH<sub>2</sub>-terminal part have been studied extensively in the context of amyloidosis.
|
29915572 |
2018 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relative transcriptional activities of SAA1 promoters polymorphic at position -13(T/C): potential association between increased transcription and amyloidosis.
|
16076608 |
2005 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the gamma/gamma genotype and gamma alleles at the SAA1 locus were significantly higher in the amyloidosis population than in the early RA population (34.9% versus 7.8%, and 58.1% versus 33.8%, chi2 test P=0.0001).
|
10543406 |
1999 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
M694V homozygocity, male gender and the alpha/alpha genotype of serum amyloid A1 gene are the currently established risk factors for development of amyloidosis.
|
16283319 |
2006 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cell culture model of amyloid formation from serum amyloid A1 (SAA1) protein remodels crucial features of AA amyloid deposit formation in vivo.
|
30739503 |
2019 |
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Colonic amyloidosis is the result of overexpression of the serum amyloid A (SAA) protein in inflammatory bowel disease or colon cancer.
|
30533585 |
2018 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apart from the apparent inherent amyloidogenicity of SAA, it can not be excluded that certain amino acid substitutions could enhance its amyloidogenicity but also could contribute to tissue predilection in amyloidosis.
|
10524286 |
1999 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest a protective effect of the SAA1 beta and gamma alleles on the development of amyloidosis and show the absence of a MICA modifying effect on amyloidosis development.
|
15018633 |
2004 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1 alpha/alpha genotype is a risk factor for AA type amyloidosis in Caucasoid populations and more studies are needed to investigate why the gamma/gamma genotype is associated with AA type amyloidosis in Japan.
|
16736418 |
2006 |
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum amyloid A-activating factor-1 (SAF-1), a Cys(2)His(2)-type zinc finger transcription factor, regulates inflammation-induced expression of serum amyloid A protein that is linked to the pathogenesis of reactive amyloidosis, rheumatoid arthritis, and atherosclerosis.
|
12270922 |
2002 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis for amyloidosis corrected risk revealed a 1.2 times increase in M694V/M694V, a 2.4 times increase in SAA1 alpha/alpha genotypes and a 2.5 times increase when both are together.
|
16118480 |
2005 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population.
|
15170927 |
2004 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Caucasians, the -13T allele had a stronger association with amyloidosis than did the SAA1.1 allele.
|
12762135 |
2003 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
GO induced a strong acute inflammatory response together with a pulmonary (Serum-Amyloid A, Saa3) and hepatic (Saa1) acute phase response. rGO induced less acute, but a constant and prolonged inflammation up to day 90.
|
28570647 |
2017 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD.
|
17039260 |
2007 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that the SAA1 rs12218 polymorphism was significantly more prevalent in ankylosing spondylitis patients with amyloidosis.
|
26300108 |
2015 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to determine the effect of SAA1 -13T/C in FMF patients with and without amyloidosis.
|
16874691 |
2006 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SAA and SAP composition of the deposits assessed secondary type of amyloidosis.
|
22850426 |
2012 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analyzed the contribution of genotypes at the MEFV and SAA1 loci to disease severity and to the development of amyloidosis, and further defined the factors affecting the clinical profile of FMF.
|
12687559 |
2003 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk of amyloidosis is increased in male FMF patients and in patients bearing polymorphism a/a in the SAA1 gene.
|
12832747 |
2003 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the study emphasizes the importance of SAA gene structure in determining susceptibility to amyloidosis.
|
3456645 |
1986 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine if SAA concentrations and SAA1 gene polymorphisms could explain the virtual absence of amyloidosis in HIDS patients.
|
16011988 |
2005 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1 α allele is strongly associated with amyloidosis in FMF patients.
|
27791951 |
2017 |