Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Serum amyloid A1 and tumor necrosis factor-alpha alleles in Turkish familial Mediterranean fever patients with and without amyloidosis.
|
12762136 |
2003 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SAA and SAP composition of the deposits assessed secondary type of amyloidosis.
|
22850426 |
2012 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
M694V homozygocity, male gender and the alpha/alpha genotype of serum amyloid A1 gene are the currently established risk factors for development of amyloidosis.
|
16283319 |
2006 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis.
|
17968686 |
2007 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apart from the apparent inherent amyloidogenicity of SAA, it can not be excluded that certain amino acid substitutions could enhance its amyloidogenicity but also could contribute to tissue predilection in amyloidosis.
|
10524286 |
1999 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ApoE genotypes, systemic (C-reactive protein [CRP], fibrinogen, serum amyloid-A [SAA]) and vascular inflammatory markers (Lipoprotein-associated phospholipase A(2) [Lp-PLA(2)] and pentraxin-3 [PTX-3]) were assessed in 324 Caucasians and 208 African Americans, undergoing coronary angiography.
|
22632920 |
2012 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Clinicopathological and epidemiological analysis of amyloidosis in Turkish patients.
|
15972323 |
2005 |
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Colonic amyloidosis is the result of overexpression of the serum amyloid A (SAA) protein in inflammatory bowel disease or colon cancer.
|
30533585 |
2018 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
GO induced a strong acute inflammatory response together with a pulmonary (Serum-Amyloid A, Saa3) and hepatic (Saa1) acute phase response. rGO induced less acute, but a constant and prolonged inflammation up to day 90.
|
28570647 |
2017 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human SAA and its NH<sub>2</sub>-terminal part have been studied extensively in the context of amyloidosis.
|
29915572 |
2018 |
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In Caucasian patients with JCA, the presence of the homozygous SAA1 alpha genotype indicates high risk of amyloidosis and should encourage early and aggressive anti-inflammatory therapy to keep circulating SAA levels as low as possible.
|
10036584 |
1998 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Caucasians, the -13T allele had a stronger association with amyloidosis than did the SAA1.1 allele.
|
12762135 |
2003 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In Caucasians, the -13T allele had a stronger association with amyloidosis than did the SAA1.1 allele.
|
12762135 |
2003 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD.
|
17039260 |
2007 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD.
|
17039260 |
2007 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to determine the effect of SAA1 -13T/C in FMF patients with and without amyloidosis.
|
16874691 |
2006 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analyzed the contribution of genotypes at the MEFV and SAA1 loci to disease severity and to the development of amyloidosis, and further defined the factors affecting the clinical profile of FMF.
|
12687559 |
2003 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population.
|
15170927 |
2004 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis for amyloidosis corrected risk revealed a 1.2 times increase in M694V/M694V, a 2.4 times increase in SAA1 alpha/alpha genotypes and a 2.5 times increase when both are together.
|
16118480 |
2005 |
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our model is supported by the SAA cleavage in the interdomain linker to generate the 1-76 fragment deposited in reactive amyloidosis.
|
26918388 |
2016 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relative transcriptional activities of SAA1 promoters polymorphic at position -13(T/C): potential association between increased transcription and amyloidosis.
|
16076608 |
2005 |
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum SAA levels, plasma cytokines, glomerular filtration rate and serum amyloid P scanning were monitored.
|
15316120 |
2004 |
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum amyloid A-activating factor-1 (SAF-1), a Cys(2)His(2)-type zinc finger transcription factor, regulates inflammation-induced expression of serum amyloid A protein that is linked to the pathogenesis of reactive amyloidosis, rheumatoid arthritis, and atherosclerosis.
|
12270922 |
2002 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1-alpha/alpha genotype was associated with an increased risk of amyloidosis.
|
12836090 |
2003 |
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SAA1 alpha/alpha genotype is a risk factor for AA type amyloidosis in Caucasoid populations and more studies are needed to investigate why the gamma/gamma genotype is associated with AA type amyloidosis in Japan.
|
16736418 |
2006 |