SERPINB3, serpin family B member 3, 6317

N. diseases: 101; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 GeneticVariation group BEFREE T357A variant has a significantly higher frequency in nonencapsulated tumors than wild type SCCA1 (p = 0.034).The SCCA1, 2 mRNA is effective for detecting HCC and could be potentially applied in HCC diagnosis. 25150316 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation disease BEFREE T357A variant has a significantly higher frequency in nonencapsulated tumors than wild type SCCA1 (p = 0.034).The SCCA1, 2 mRNA is effective for detecting HCC and could be potentially applied in HCC diagnosis. 25150316 2014
CUI: C0341439
Disease: Chronic liver disease
Chronic liver disease
0.030 GeneticVariation group BEFREE Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease. 18657489 2009
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.020 GeneticVariation disease BEFREE To explore SCCA-1 polymorphism in patients with HCV infection as single etiologic factor and different extent of liver disease. 18657489 2009
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.010 GeneticVariation group BEFREE To explore SCCA-1 polymorphism in patients with HCV infection as single etiologic factor and different extent of liver disease. 18657489 2009
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 GeneticVariation group BEFREE A novel SCCA1 variant has been identified in one third of liver tumours. 14970861 2004
CUI: C0025202
Disease: melanoma
melanoma
0.010 GeneticVariation disease BEFREE Here we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival after anti-CTLA4 immunotherapy in two independent cohorts of patients with melanoma (n = 174). 27668655 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE We recently found that the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2 are novel biomarkers of bronchial asthma, downstream of IL-4 and IL-13. 16238792 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease CTD_human Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis. 15274141 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE The SCCA1 promoter was analyzed by dual luciferase assay and substituted with the E1A promoter to construct the oncolytic adenovirus to determine the squamous cell carcinoma-specific cell lysis. 20527047 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE This study examined the effect of squamous cell carcinoma antigen 1 (SCCA1) and SCCA2 on TNF-alpha-induced cell death in human oral squamous cell carcinoma cell lines. 16006770 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4), members of the ovalbumin serpin (ov-serpin)/clade B serpin family, were originally discovered as tumor-specific antigens and are used as tumor markers for various kinds of squamous cell carcinomas. 29642409 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE These findings suggest that the transcriptional regulation of SCCA1 and SCCA2 might differ among squamous cell carcinoma, keratinocyte and adenocarcinoma cells, and that SCCA1 promoter might be a potential target of gene therapy for squamous cell carcinoma. 11267667 2001
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease LHGDN Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. 14719077 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC. 30376194 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease LHGDN Evaluation of serum squamous cell carcinoma antigen as a novel biomarker for diagnosis of hepatocellular carcinoma in Egyptian patients. 19112206 2009
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.320 Biomarker group BEFREE Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity. 30825353 2019
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.320 Biomarker group CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus
0.310 Biomarker disease BEFREE Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity. 30825353 2019
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus
0.310 Biomarker disease CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0000786
Disease: Spontaneous abortion
Spontaneous abortion
0.300 Biomarker phenotype CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642 2008
CUI: C0000822
Disease: Abortion, Tubal
Abortion, Tubal
0.300 Biomarker phenotype CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642 2008
CUI: C0011616
Disease: Contact Dermatitis
Contact Dermatitis
0.300 Biomarker disease CTD_human Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay. 25724174 2015
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms
0.300 Biomarker group CTD_human Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis. 15274141 2004
CUI: C0032927
Disease: Precancerous Conditions
Precancerous Conditions
0.300 Biomarker group CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005