|
Esophageal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity.
|
30825353 |
2019 |
|
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, SCCA protein is overexpressed in PTC and may represent a predictive prognostic factor for PTC patients.
|
30535496 |
2019 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report SCCA1 in relation to the immune and peritumoral adipose tissue microenvironment in early and advanced esophageal adenocarcinoma (EAC).
|
30825353 |
2019 |
|
Familial multiple trichoepitheliomata
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, poor prognosis in EAC overexpressing SCCA1 is due to reduced tumor chemosensitivity as well as intratumoral immunity impairment, likely induced by this molecule.
|
30825353 |
2019 |
|
Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SERPINB3 Delays Glomerulonephritis and Attenuates the Lupus-Like Disease in Lupus Murine Models by Inducing a More Tolerogenic Immune Phenotype.
|
30254646 |
2018 |
|
Liver Cirrhosis, Alcoholic
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the diagnostic sensitivity and specificity of protein induced by vitamin K absence or antagonist-II (PIVKAII), Glypican-3 (GP3), Cystatin B (CSTB), squamous cell carcinoma antigen 1 (SCCA1) and hepatocyte growth factor (HGF) as potential tumour markers for HCC in patients with alcoholic liver cirrhosis (ALC) using imaging techniques (MSCT and MRI) as reference standards.
|
28766361 |
2018 |
|
Lupus Vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
SERPINB3 Delays Glomerulonephritis and Attenuates the Lupus-Like Disease in Lupus Murine Models by Inducing a More Tolerogenic Immune Phenotype.
|
30254646 |
2018 |
|
Lupus Erythematosus, Discoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
SERPINB3 Delays Glomerulonephritis and Attenuates the Lupus-Like Disease in Lupus Murine Models by Inducing a More Tolerogenic Immune Phenotype.
|
30254646 |
2018 |
|
Iron Overload
|
0.010 |
Biomarker
|
disease |
BEFREE |
The molecular link between iron, ROS and SerpinB3 seems to be HIF-2α, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.
|
28935635 |
2018 |
|
Human papilloma virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SERPINB3 expression differs depending on Human papillomavirus (HPV) infection status, primary tumour location, grade and differentiation, extension to lymph nodes and extracapsular spread.
|
29491058 |
2018 |
|
Lupus Erythematosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
SERPINB3 Delays Glomerulonephritis and Attenuates the Lupus-Like Disease in Lupus Murine Models by Inducing a More Tolerogenic Immune Phenotype.
|
30254646 |
2018 |
|
Squamous cell carcinoma of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with immunocompetent SCC, genes associated with innate immunity, response to DNA damage, and p53 regulation were differentially expressed in SCC from OTRs.
|
30185657 |
2018 |
|
Allergy to grass pollen
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD27<sup>-</sup>CD4<sup>+</sup> from patients with grass pollen allergy expressed higher levels of both SERPINB3 and SERPINB4 mRNA (both P < .0005) compared with CD27<sup>+</sup>CD4<sup>+</sup> cells.
|
29106998 |
2018 |
|
Malignant transformation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
SerpinB3 is a serine protease inhibitor overexpressed in the liver in oxidative stress conditions, able to induce fibrosis and increased risk of malignant transformation.
|
28935635 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SerpinB3 upregulates the Cyclooxygenase-2 / β-Catenin positive loop in colorectal cancer.
|
28178650 |
2017 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Published immune cell signatures and several lung AD and SCC gene expression data sets, including The Cancer Genome Atlas, were used to examine immune response in relation to AD and SCC expression subtypes.
|
28341226 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Published immune cell signatures and several lung AD and SCC gene expression data sets, including The Cancer Genome Atlas, were used to examine immune response in relation to AD and SCC expression subtypes.
|
28341226 |
2017 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
From the collective results of the present study, we suggest that serpin B3 is a promising novel biomarker candidate for the diagnosis of prostate cancer bone metastasis.
|
28627741 |
2017 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study we analyzed the pro-fibrogenic action of SerpinB3 in cell cultures and in two different murine models of liver fibrosis.
|
28611447 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
From the collective results of the present study, we suggest that serpin B3 is a promising novel biomarker candidate for the diagnosis of prostate cancer bone metastasis.
|
28627741 |
2017 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
From the collective results of the present study, we suggest that serpin B3 is a promising novel biomarker candidate for the diagnosis of prostate cancer bone metastasis.
|
28627741 |
2017 |
|
Chronic lung disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SerpinB3 up-regulation in CLD patients has been reported to correlate with the extent of liver fibrosis and the production of transforming growth factor-β1, but the actual role of SerpinB3 in hepatic fibrogenesis is still poorly characterized.
|
28611447 |
2017 |
|
Lymphoproliferative Disorder of the Skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SerpinB3 up-regulation in CLD patients has been reported to correlate with the extent of liver fibrosis and the production of transforming growth factor-β1, but the actual role of SerpinB3 in hepatic fibrogenesis is still poorly characterized.
|
28611447 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
SerpinB3 upregulates the Cyclooxygenase-2 / β-Catenin positive loop in colorectal cancer.
|
28178650 |
2017 |
|
melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival after anti-CTLA4 immunotherapy in two independent cohorts of patients with melanoma (n = 174).
|
27668655 |
2016 |