|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer.
|
8577718 |
1996 |
|
Colonic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer.
|
8577718 |
1996 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer.
|
8577718 |
1996 |
|
Deletion of long arm of chromosome 18
|
0.010 |
Biomarker
|
disease |
BEFREE |
An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA.
|
9887335 |
1999 |
|
Chromosome 18, trisomy 18q
|
0.010 |
Biomarker
|
disease |
BEFREE |
An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA.
|
9887335 |
1999 |
|
Chromosome 18q syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA.
|
9887335 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Examination of squamous cell carcinomas of the lung and head and neck showed that SCCA1 and SCCA2 were co-expressed in moderately and well-differentiated tumors.
|
10653592 |
2000 |
|
Virus Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Surprisingly, however, virus infection, which tends to inhibit host protein synthesis, caused a significant increase in SCCA1 expression well into the late phase of infection.
|
10683336 |
2000 |
|
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the transcriptional regulation of SCCA1 and SCCA2 might differ among squamous cell carcinoma, keratinocyte and adenocarcinoma cells, and that SCCA1 promoter might be a potential target of gene therapy for squamous cell carcinoma.
|
11267667 |
2001 |
|
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcription (RT)-PCR of the squamous cell carcinoma cell line showed the existence of a 156 base shorter transcript compared with that of SCCA1 cDNA.
|
11406281 |
2001 |
|
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that SCCA1 is mainly expressed in squamous cell carcinoma, keratinocyte and non-squamous cell carcinoma cell lines and that the ratio of SCCA1 to SCCA2 expression might be a novel marker for the detection of squamous cell carcinoma.
|
11182054 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
One of the SCCAs, SCCA1, has been suggested to play a role in the attenuation of apoptosis in vitro and in the augmentation of tumor growth in vivo.
|
11280721 |
2001 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings suggest that the transcriptional regulation of SCCA1 and SCCA2 might differ among squamous cell carcinoma, keratinocyte and adenocarcinoma cells, and that SCCA1 promoter might be a potential target of gene therapy for squamous cell carcinoma.
|
11267667 |
2001 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Maspin, SCCA1/2 and hurpin were identified by cDNA microarray analyses as dramatically differentially expressed transcripts in primary non-small cell lung cancer (NSCLC).
|
14647462 |
2003 |
|
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Transient increase in squamous cell carcinoma antigen expression in cultured cervical carcinoma CaSki cells in response to exposure to cis-diamminedichloroplatinum.
|
15001834 |
2004 |
|
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis.
|
15274141 |
2004 |
|
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus.
|
14993646 |
2004 |
|
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line.
|
14719077 |
2004 |
|
Mouth Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis.
|
15274141 |
2004 |
|
Malignant neoplasm of mouth
|
0.300 |
Biomarker
|
group |
CTD_human |
Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis.
|
15274141 |
2004 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.
|
14970861 |
2004 |
|
Hepatitis B
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus.
|
14993646 |
2004 |
|
Liver neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A novel SCCA1 variant has been identified in one third of liver tumours.
|
14970861 |
2004 |
|
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We recently found that the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2 are novel biomarkers of bronchial asthma, downstream of IL-4 and IL-13.
|
16238792 |
2005 |
|
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study examined the effect of squamous cell carcinoma antigen 1 (SCCA1) and SCCA2 on TNF-alpha-induced cell death in human oral squamous cell carcinoma cell lines.
|
16006770 |
2005 |