|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.
|
17990036 |
2008 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Virus-infected subjects with acute asthma or no asthma had increased RANTES (regulated on activation, normal T cell expressed and secreted) and macrophage inflammatory protein-1alpha messenger RNAs compared with other groups.
|
15894599 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have recently identified a polymorphism within the RANTES promoter (-403 G-->A) and have examined its role, using a PCR-RFLP assay, in the development of atopy and asthma in 201 Caucasian subjects.
|
11197694 |
2000 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to investigate the possible influence of the CCL5/RANTES promoter polymorphisms in the different types of bronchial asthma.
|
18186796 |
2008 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that HRV-induced CCL5 can induce ASMC chemotaxis and thus may contribute to the pathogenesis of airway remodeling in patients with asthma.
|
28257236 |
2017 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
C-C chemokines such as CCL11, CCL5, and CCL3 are central mediators in the pathogenesis of asthma.
|
18178867 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs.
|
18385174 |
2008 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
LHGDN |
RANTES production from mononuclear cells in response to the specific allergen in asthma patients.
|
17075265 |
2006 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The RANTES -403G/A polymorphism did not influence asthma/atopy susceptibility, blood eosinophil count, or bronchial hyperresponsiveness.
|
12789231 |
2003 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These changes are mirrored in serum and should be considered in the light of the downmodulating role of CD26 in major chemokines related to the pathogenesis of asthma such as CCL11 (eotaxin), CCL5 (RANTES), and CXCL12a (SDF-1α).
|
29297467 |
2019 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous studies revealed that polymorphisms of RANTES were implicated in susceptibility to asthma, but a large number of studies reported apparently conflicting results.
|
20430255 |
2010 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter polymorphisms in the RANTES gene did not have a detectable effect on the susceptibility to asthma or allergy or on the blood eosinophil count.
|
11544456 |
2001 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have evaluated the functional polymorphism -28C/G in the RANTES promoter region, which had been found to affect the transcription of the RANTES gene, in relation to asthma susceptibility.
|
20186291 |
2010 |
|
Hyperoxaluria
|
0.500 |
Biomarker
|
disease |
CTD_human |
NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system.
|
16284884 |
2005 |
|
Hyperoxaluria
|
0.500 |
Biomarker
|
disease |
RGD |
NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system.
|
16284884 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children.
|
15715189 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.
|
10640782 |
2000 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
|
17117952 |
2006 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
|
17117952 |
2006 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
After treatment with topical tacrolimus twice daily for 8 weeks, significant decreases were found in serum IL-5 levels, immunoreactive cell counts of eotaxin, IL-5, CCR3 and RANTES in AD skin, and tissue eosinophil counts.
|
15948978 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
RANTES and MCP-1 mRNA(+) keratinocytes were detected in the basal layer of lesions of patients with AD and psoriasis.
|
11344355 |
2001 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to evaluate the relationships of RANTES and RA and AD using a meta-analysis.
|
25607251 |
2015 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We show that miR-146a expression is increased in keratinocytes and chronic lesional skin of patients with AD. miR-146a inhibited the expression of numerous proinflammatory factors, including IFN-γ-inducible and AD-associated genes CCL5, CCL8, and ubiquitin D (UBD) in human primary keratinocytes stimulated with IFN-γ, TNF-α, or IL-1β.
|
24996260 |
2014 |
|
Dermatitis, Atopic
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Our results show that some of the skin lesions of beige rats are morphologically similar to human AD, being characterized by inflammatory cell composition in the acute phase, and increased IgE and RANTES levels.
|
15591815 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings suggest that RANTES is involved in eosinophil infiltration and T cell infiltration in atopic dermatitis.
|
8906106 |
1996 |