|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
C-C chemokines such as CCL11, CCL5, and CCL3 are central mediators in the pathogenesis of asthma.
|
18178867 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs.
|
18385174 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The RANTES -403G/A polymorphism did not influence asthma/atopy susceptibility, blood eosinophil count, or bronchial hyperresponsiveness.
|
12789231 |
2003 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These changes are mirrored in serum and should be considered in the light of the downmodulating role of CD26 in major chemokines related to the pathogenesis of asthma such as CCL11 (eotaxin), CCL5 (RANTES), and CXCL12a (SDF-1α).
|
29297467 |
2019 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous studies revealed that polymorphisms of RANTES were implicated in susceptibility to asthma, but a large number of studies reported apparently conflicting results.
|
20430255 |
2010 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter polymorphisms in the RANTES gene did not have a detectable effect on the susceptibility to asthma or allergy or on the blood eosinophil count.
|
11544456 |
2001 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have evaluated the functional polymorphism -28C/G in the RANTES promoter region, which had been found to affect the transcription of the RANTES gene, in relation to asthma susceptibility.
|
20186291 |
2010 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children.
|
15715189 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.
|
10640782 |
2000 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
|
17117952 |
2006 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
After treatment with topical tacrolimus twice daily for 8 weeks, significant decreases were found in serum IL-5 levels, immunoreactive cell counts of eotaxin, IL-5, CCR3 and RANTES in AD skin, and tissue eosinophil counts.
|
15948978 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
RANTES and MCP-1 mRNA(+) keratinocytes were detected in the basal layer of lesions of patients with AD and psoriasis.
|
11344355 |
2001 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to evaluate the relationships of RANTES and RA and AD using a meta-analysis.
|
25607251 |
2015 |
|
Dermatitis, Atopic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We show that miR-146a expression is increased in keratinocytes and chronic lesional skin of patients with AD. miR-146a inhibited the expression of numerous proinflammatory factors, including IFN-γ-inducible and AD-associated genes CCL5, CCL8, and ubiquitin D (UBD) in human primary keratinocytes stimulated with IFN-γ, TNF-α, or IL-1β.
|
24996260 |
2014 |
|
Dermatitis, Atopic
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Our results show that some of the skin lesions of beige rats are morphologically similar to human AD, being characterized by inflammatory cell composition in the acute phase, and increased IgE and RANTES levels.
|
15591815 |
2005 |
|
Dermatitis, Atopic
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings suggest that RANTES is involved in eosinophil infiltration and T cell infiltration in atopic dermatitis.
|
8906106 |
1996 |
|
Glomerulonephritis
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In contrast TLR3 mRNA expression was significantly increased in hepatitis C-positive glomerulonephritis and was associated with enhanced mRNA for RANTES/CCL5 and MCP-1/CCL2.
|
16436653 |
2006 |
|
Glomerulonephritis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Using in situ hybridization (ISH) we analyzed the expression of mRNA for the C-C chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha and beta (MIP-1alpha, MIP-1beta) and RANTES in renal biopsy material from twenty patients with glomerulonephritis.
|
9734607 |
1998 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Early elevated cutaneous mRNA expression of TGF-beta1, but not TGF-beta2 or TGF-beta3, and elevated C-C chemokines macrophage chemoattractant protein-1, macrophage inflammatory protein-1alpha, and RANTES precede subsequent skin and lung fibrosis.
|
11884483 |
2002 |
|
Hepatitis, Alcoholic
|
0.310 |
Biomarker
|
disease |
BEFREE |
In addition, hepatic RANTES which migrates CD4 T lymphocytes to liver is increased in patients with alcoholic hepatitis.
|
12663241 |
2003 |
|
Malignant mesothelioma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Notably, the chemokine RANTES measured the highest serum level showing an increased gradient of concentration from healthy subjects to Asb-workers and MM patients (p<0.001), independently of SV40 infection.
|
25162674 |
2014 |
|
Arteriosclerosis
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Increased RANTES expression has been described to have a role in atherosclerosis plaque formation.
|
21839152 |
2011 |
|
Arteriosclerosis
|
0.290 |
Biomarker
|
disease |
BEFREE |
In a previous study, we have demonstrated a pathophysiologic relevance for the heterophilic interaction of CCL5 and CXCL4 in the progression of atherosclerosis.
|
30006564 |
2018 |
|
Arteriosclerosis
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
In view of its in vitro biologic activity and in vivo expression pattern, RANTES may be a pivotal mediator of the cellular infiltrate seen in graft atherosclerosis.
|
8981204 |
1996 |
|
Arteriosclerosis
|
0.290 |
Biomarker
|
disease |
BEFREE |
Upregulated RANTES from monocytes in HHcy patients may be involved in the atherogenesis of HHcy-induced atherosclerosis.
|
16225753 |
2005 |