Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
To address this question, we studied an independent panel of 20 breast cancer cell lines and xenografts for MAP2K4 alterations.
|
11754110 |
2002 |
Malignant neoplasm of breast
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In this study, we found an inverse association between MKK4 promoter polymorphism and breast cancer risk.
|
27509166 |
2016 |
Malignant neoplasm of breast
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In our study, MAP2K4 and Vimentin co-expression is confirmed to be an unfavorable factor in breast cancer.
|
31761784 |
2019 |
Malignant neoplasm of breast
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In contrast, only three known cancer genes were found among male breast cancers; MAP2K4, LHP, and ZNF217.
|
24194916 |
2013 |
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
To determine the role of the MEKK1/SEK1/JNK1/AP-1 pathway in the action of Xihuang pill (XHP) in reducing regulatory T (Treg) cell numbers in the tumor microenvironment in a 4T1 mouse breast cancer model, and to clarify the anti-tumor mechanism of XHP in breast cancer.
|
29710529 |
2018 |
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
The Metastasis Suppressor Genes (MSG) Nm23, KISS1, KAI1, BRMS1, and Mkk4 have been associated with the metastatic potential of breast cancer in vitro and in vivo.
|
15592684 |
2005 |
Malignant neoplasm of pancreas
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
No mutations were identified in mitogen-activated protein kinase kinase 4 (0 of 22), MADH4 (0 of 22), or ACVR1B (0 of 29), making it unlikely that germ-line mutations in these genes account for a significant number of inherited pancreatic cancers.
|
12097290 |
2002 |
Malignant neoplasm of pancreas
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our findings support the notion that selective activation of tumor-suppressive MEKK4-MKK4-p38-p21signaling pathway by triptonide is a new approach for pancreatic cancer therapy, providing a new drug candidate for development of novel anti-cancer therapeutics.
|
31075266 |
2019 |
Malignant neoplasm of pancreas
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Emerging data from a variety of investigators now indicate that overexpression of EphA2, loss of DPC4 and MKK4, and aberrant activation of the Hedgehog signaling pathway are associated with metastatic propensity of pancreatic cancers, providing novel therapeutic targets for the most lethal stage of this disease.
|
19260747 |
2009 |
Malignant neoplasm of pancreas
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Pancreatic cancer tissues analysis showed that PTEN and MAP2K4 were all negatively correlated with miR-181a.
|
24532253 |
2014 |
Malignant neoplasm of pancreas
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate for the first time that common variants in BRCA2 and MAP2K4 are susceptibility to sporadic pancreatic cancer.
|
23299404 |
2013 |
Malignant neoplasm of pancreas
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.
|
15623633 |
2004 |
Breast Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In our study, MAP2K4 and Vimentin co-expression is confirmed to be an unfavorable factor in breast cancer.
|
31761784 |
2019 |
Breast Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In this study, we found an inverse association between MKK4 promoter polymorphism and breast cancer risk.
|
27509166 |
2016 |
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.
|
9622070 |
1998 |
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
The Metastasis Suppressor Genes (MSG) Nm23, KISS1, KAI1, BRMS1, and Mkk4 have been associated with the metastatic potential of breast cancer in vitro and in vivo.
|
15592684 |
2005 |
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
To determine the role of the MEKK1/SEK1/JNK1/AP-1 pathway in the action of Xihuang pill (XHP) in reducing regulatory T (Treg) cell numbers in the tumor microenvironment in a 4T1 mouse breast cancer model, and to clarify the anti-tumor mechanism of XHP in breast cancer.
|
29710529 |
2018 |
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
To address this question, we studied an independent panel of 20 breast cancer cell lines and xenografts for MAP2K4 alterations.
|
11754110 |
2002 |
Pancreatic carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate for the first time that common variants in BRCA2 and MAP2K4 are susceptibility to sporadic pancreatic cancer.
|
23299404 |
2013 |
Pancreatic carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.
|
15623633 |
2004 |
Pancreatic carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our findings support the notion that selective activation of tumor-suppressive MEKK4-MKK4-p38-p21signaling pathway by triptonide is a new approach for pancreatic cancer therapy, providing a new drug candidate for development of novel anti-cancer therapeutics.
|
31075266 |
2019 |
Pancreatic carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Pancreatic cancer tissues analysis showed that PTEN and MAP2K4 were all negatively correlated with miR-181a.
|
24532253 |
2014 |
Pancreatic Neoplasm
|
0.310 |
Biomarker
|
disease |
BEFREE |
These results argue that MKK4 functions as a pro-oncogenic molecule instead of a suppressor in breast and pancreatic tumors.
|
15184866 |
2004 |
Ovarian Serous Adenocarcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that homozygous deletion or reduced expression of MKK4 may contribute to the development of ovarian serous carcinoma.
|
16627982 |
2006 |
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MAP2K4 encodes a dual-specificity kinase (mitogen-activated protein kinase kinase 4, or MKK4) that is mutated in a variety of human malignancies, but the biochemical properties of the mutant kinases and their roles in tumorigenesis have not been fully elucidated.
|
21896780 |
2011 |