|
Progressive supranuclear palsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, a specific shut off in mitogen-activated protein kinase kinase 4 (SEK1/MKK4)/stress-activated protein kinase (SAPK) axis was exclusively observed in PSP, whereas a specific phosphoinositide-dependent protein kinase 1 (PDK1) inactivation was observed in FTLD-TDP43.
|
30999060 |
2019 |
|
Malignant neoplasm of gallbladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |
|
Gallbladder Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |
|
Frontotemporal Lobar Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, a specific shut off in mitogen-activated protein kinase kinase 4 (SEK1/MKK4)/stress-activated protein kinase (SAPK) axis was exclusively observed in PSP, whereas a specific phosphoinositide-dependent protein kinase 1 (PDK1) inactivation was observed in FTLD-TDP43.
|
30999060 |
2019 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In pancreatic ductal adenocarcinoma (PDAC), it remains controversial whether MKK4 and MKK7 have pro-oncogenic or tumor-suppressive activities.
|
30537492 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, high MKK4 expression and its combination with high MKK7 expression both predicted favorable prognosis in resectable PDAC.
|
30537492 |
2019 |
|
GRN-related frontotemporal dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, a specific shut off in mitogen-activated protein kinase kinase 4 (SEK1/MKK4)/stress-activated protein kinase (SAPK) axis was exclusively observed in PSP, whereas a specific phosphoinositide-dependent protein kinase 1 (PDK1) inactivation was observed in FTLD-TDP43.
|
30999060 |
2019 |
|
Stage 0 Gallbladder Cancer AJCC v8
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |
|
Stage IIA Gallbladder Cancer AJCC v8
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |
|
Stage IIB Gallbladder Cancer AJCC v8
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |
|
Stage III Gallbladder Cancer AJCC v8
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |
|
Stage IV Gallbladder Cancer AJCC v8
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |
|
Resectable Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinicopathological and prognostic significance of MKK4 and MKK7 in resectable pancreatic ductal adenocarcinoma.
|
30537492 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The largest fold changes (> 1.6) in the S-glutathionylated proteome after fatigue occurred on signaling proteins such as 14-3-3 protein gamma and MAP2K4, as well as proteins like SERCA1, and NDUV2 of mitochondrial complex I, at previously unknown glutathionylation sites.
|
29857311 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
MKK4 as a natural therapeutic agent to control obesity.
|
29409330 |
2018 |
|
Multiple malignancy
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
|
29795445 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers.
|
29472518 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MKK4 was significantly elevated in OA cartilage.
|
29072705 |
2017 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By contrast, MAP2K4 was downregulated in CAC.
|
28454307 |
2017 |
|
Squamous cell carcinoma of tongue
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also demonstrated that the MAP2K4 expression was upregulated in TSCC cell lines.
|
28319306 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that CRC patients with low pMKK4 immunochemistry scores should be monitored carefully for early detection of possible recurrences, especially liver metastasis.
|
28423721 |
2017 |
|
Invasive carcinoma of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Next generation sequencing on a subset of cases with invasive breast cancer and adjacent ductal carcinoma in situ (n=4) showed identical genomic aberrations, including PIK3CA, GATA3, TP53, and MAP2K4 mutations.
|
28084333 |
2017 |
|
Adenoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we used immunohistochemistry to assess phosphorylated MMK4 (pMKK4) levels and examine their association with the clinicopathological features of a pilot set of patient samples consisting of normal colonic mucosa (NCM), colorectal adenoma (CA), and colorectal cancer (CRC) tissues. pMKK4 levels were also assessed in a validation set of CRC cases with accompanying follow-up data to confirm their clinicopathological and prognostic significance. pMKK4 levels, which were high in 79.17% of NCM samples, were downregulated in 33.33% of CA and 63.54% of CRC samples. pMKK4 downregulation was associated with metastasis, especially to the liver.
|
28423721 |
2017 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Significant association was not observed between MAP2K4 gene polymorphism rs3826392 and IS susceptibility in all genetic models (P > .05).
|
26856463 |
2016 |
|
Hormone refractory prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-27a functions as a tumor suppressor by suppressing MAP2K4 which acts as an oncogene in prostate cancer cell lines; we also provided a new mechanism of castration-resistant prostate cancer mediated by miR-27a that downregulation of miR-27a caused by aberrant AR signaling and PI3K/Akt signaling after androgen deprivation therapy (ADT) would promote the progression of castration-resistant prostate cancer.
|
27594411 |
2016 |