|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
RGD |
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy.
|
12110012 |
2002 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
RGD |
Protein and mRNA expression levels of Oat1, Oat 3, Oct1, and Oct2 were significantly decreased in adenine-induced CRF rats.
|
23280877 |
2013 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
GWASCAT |
New loci associated with kidney function and chronic kidney disease.
|
20383146 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Similarly, OCT2 (∼2-fold) and OCT3 (∼3-fold) showed increased protein expression in the kidneys of obese patients compared with those of nonobese individuals.
|
27401566 |
2016 |
|
Hyperuricemia
|
0.210 |
Biomarker
|
disease |
BEFREE |
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
|
30951542 |
2019 |
|
Hyperuricemia
|
0.210 |
Biomarker
|
disease |
RGD |
Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney.
|
15748710 |
2005 |
|
Cholestasis, Extrahepatic
|
0.200 |
Biomarker
|
disease |
RGD |
Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2.
|
20814153 |
2010 |
|
Intrahepatic Cholestasis
|
0.200 |
Biomarker
|
disease |
RGD |
Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.
|
19002567 |
2009 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Renal and hepatic transporter expression in type 2 diabetic rats.
|
19356064 |
2008 |
|
Kidney Failure
|
0.200 |
Biomarker
|
disease |
RGD |
Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats.
|
21167265 |
2011 |
|
Chronic kidney disease stage 5
|
0.200 |
Biomarker
|
disease |
RGD |
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy.
|
12110012 |
2002 |
|
Chronic kidney disease stage 5
|
0.200 |
Biomarker
|
disease |
RGD |
Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure.
|
23280877 |
2013 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats.
|
18612803 |
2008 |
|
Acute kidney injury
|
0.200 |
Therapeutic
|
disease |
RGD |
Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury.
|
22414646 |
2012 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.
|
31451708 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The SLC22A2 single nucleotide polymorphism (SNP) 808G/T was genotyped in 400 T2DM patients, including a metformin-treated group (n=200) and a non-metformin-treated group (n=200).
|
20139901 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.
|
27609360 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the role of OCT2-T201M (602 C>T) variant in insulin resistance in patients with type 2 diabetes (T2D) who were treated with metformin.
|
25662675 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
As well as gender, the glucose-lowering efficiency of metformin can be enhanced by SLC22A2 808G > T variants through the delay of its transportation and CLr in Chinese type 2 diabetes populations.
|
25573751 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate whether genetic variations in the SLC22A1, SLC22A2, and SLC47A1 genes could be associated with an altered response to metformin in patients with type 2 diabetes mellitus.
|
31012983 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate possible associations of the variants in genes encoding organic cationic transporters-solute carrier family 22, members A1, A2 (SLC22A1, SLC22A2) and solute carrier family 47, member A1 (SLC47A1) with response to metformin in type 2 diabetes.
|
22882994 |
2013 |
|
Hodgkin Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription.
|
11154228 |
2001 |
|
Hodgkin Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
To check the genomic status of PU.1, BOB1, and OCT2 in HL, we performed metaphase fluorescence in situ hybridization (FISH) analysis of 10 HL cases using locus-specific bacterial artificial chromosome clones.
|
15796964 |
2005 |
|
Hodgkin Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Seven different cell lines derived from patients with Hodgkin's disease (HD), as well as primary H/Reed-Sternberg (RS) cells isolated from the pericardial fluid of a patient with HD, were compared with a number of hematopoietic and nonhematopoietic cell lines for the expression of Oct-2, a tissue-specific transcription factor normally restricted to B cells, and nuclear factor kappa B (NF-kappa B), an inducible transcription factor.
|
8639794 |
1996 |