|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats.
|
18612803 |
2008 |
|
Acute kidney injury
|
0.200 |
Therapeutic
|
disease |
RGD |
Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury.
|
22414646 |
2012 |
|
Adult Classical Hodgkin Lymphoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical studies revealed that the large atypical cells were CD30 (+), CD15 (weakly +), CD20 (-), CD45 (-), Pax5 (weakly +), BOB.1 (-), and Oct2 (-), indicating the coexistence of SMZL with cHL.
|
18486899 |
2008 |
|
Adult Classical Hodgkin Lymphoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
It has previously been demonstrated that in cultured and in situ tumour cells of classical Hodgkin lymphoma (cHL), the immunoglobulin (Ig) promoter is inactive and its transcription factors Oct2 and/or BOB.1/OBF.1 are down-regulated.
|
14694522 |
2004 |
|
Adult Classical Hodgkin Lymphoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of both Oct2 and PU.1 in a cHL cell line potentiated endogenous PU.1 and SYK expression after 5-aza-dC treatment.
|
16304050 |
2006 |
|
Adult Classical Hodgkin Lymphoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
All ptHL expressed CD15, CD30 and LMP-1 of EBV; the B-cell markers BOB-1, Oct2, CD79a and CD20 were more commonly expressed in ptHL versus cHL (100%, 86%, 50% and 38% in ptHL compared to 6%, 14%, 10% and 33% in cHL, respectively); all ptHL expressed phosphoinositide 3-kinase (PI3K) versus 81% of cHL; 2/6 (33%) ptHL displayed gains at 9p24 that were similar to cHL (32%).
|
19705967 |
2009 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition to their different clonal origin, Reed-Sternberg cells of Hodgkin's disease expressed a CD15+, CD20+ (rare cells), CD30+, Oct-2-, EBNA2-, LMP1+ phenotype, whereas anaplastic and Reed-Sternberg-like cells of diffuse large B-cell lymphoma were CD15-, CD20+, CD30+, Oct-2+, EBNA2+, and LMP1+.
|
12459631 |
2002 |
|
Adult Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To check the genomic status of PU.1, BOB1, and OCT2 in HL, we performed metaphase fluorescence in situ hybridization (FISH) analysis of 10 HL cases using locus-specific bacterial artificial chromosome clones.
|
15796964 |
2005 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oct-2, therefore, acts as a cell survival factor in t(14;18) lymphoma cells by directly activating the antiapoptotic gene bcl-2.
|
16186795 |
2006 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that in addition to modified oral absorption of certain drugs, it is possible that the renal excretion of drugs that are multidrug resistance-associated protein 2, organic anion transporter 3, and organic cation transporter 2 substrates could be altered in AD.
|
30825461 |
2019 |
|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results showed that the kidney injury induced by TP was aggravated in the CIA state, the concentration of TP in the renal cortex was higher than that of the medulla after TP administration in the CIA rats, and the expression of organic cation transporter 2 (Oct2) in kidney was up-regulated under CIA condition.
|
31644961 |
2019 |
|
aspirin intolerance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that SLC22A2 could be a susceptibility gene for aspirin intolerance in asthmatics.
|
21346370 |
2011 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that SLC22A2 could be a susceptibility gene for aspirin intolerance in asthmatics.
|
21346370 |
2011 |
|
Ataxia Telangiectasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, a polymorphism in intron 4 (rs3912161) and a haplotype (SLC22A2-ht3) showed significantly stronger association signals with the FEV(1) fall rate induced by aspirin provocation in AIA subjects compared with ATA controls (p = 0.004, P(corr) = 0.05).
|
21346370 |
2011 |
|
B-Cell Lymphomas
|
0.040 |
AlteredExpression
|
group |
BEFREE |
However, it differs from other aggressive B-cell lymphomas in that it shows defective Ig production despite the expression of Oct-2, BOB.1, and PU.1 transcription factors, and a lack of IgV(H) gene crippling mutations.
|
15202521 |
2003 |
|
B-Cell Lymphomas
|
0.040 |
Biomarker
|
group |
BEFREE |
J chain and MEF2B are highly sensitive and specific markers of NLPHL versus CHL; are particularly useful in highlighting LP cells; and, with rare exception, are of greater utility than OCT-2 and BOB.1 in differentiating CHL from NLPHL and other large B-cell lymphomas.
|
28851661 |
2017 |
|
B-Cell Lymphomas
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The transformed HSs showed partial retention of their prior B-cell lymphomas' signatures, including expression of OCT2 in both cases and expression of BCL6 and enhanced expression of BCL2 in case 2.
|
20331331 |
2010 |
|
B-Cell Lymphomas
|
0.040 |
AlteredExpression
|
group |
BEFREE |
However, it differs from other aggressive B-cell lymphomas in that it shows defective immunoglobulin production despite the expression of OCT-2, BOB.1, and PU.1 transcription factors and the lack of IgV(H) gene crippling mutations.
|
12507907 |
2003 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Oct-2 gene was expressed in 82% of pre-B ALL and all B-CLL samples.
|
10905058 |
2000 |
|
Behavioral and psychological symptoms of dementia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The effects of dolutegravir Ctrough and the SLC22A2 gene variant on NPs were explored by multivariable logistic regression.
|
30561642 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although, hSLC22A2 mRNA expression was frequently found in ovarian cancer cell lines, its expression in clinical ovarian cancer specimens (n= 80) was low and did not correlate with the treatment outcome of platinum-based regimens.
|
20067471 |
2010 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus elevated concentrations of these drugs as a result of a pharmacokinetic drug-drug interaction via either human multidrug resistance protein 1 or human organic cation transporter 2 (or both) in the renal tubular cells might have caused the arrhythmia in our patient.
|
16580907 |
2006 |
|
Cardiovascular Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Carnitine depletion, characterized by reduced expression of "organic cation transporter-2" gene, is a metabolic and autosomal recessive disorder that also frequently associates with CVD.
|
29241711 |
2018 |