|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that in addition to modified oral absorption of certain drugs, it is possible that the renal excretion of drugs that are multidrug resistance-associated protein 2, organic anion transporter 3, and organic cation transporter 2 substrates could be altered in AD.
|
30825461 |
2019 |
|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results showed that the kidney injury induced by TP was aggravated in the CIA state, the concentration of TP in the renal cortex was higher than that of the medulla after TP administration in the CIA rats, and the expression of organic cation transporter 2 (Oct2) in kidney was up-regulated under CIA condition.
|
31644961 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis.
|
31644961 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identified Interferon regulating factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2) and S100 calcium binding protein A12 (S100A12) as the three proteins with the largest fold change between SLE patients and controls (SLE/Control = 1.4, 1.4, and 1.2 respectively).
|
31156624 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Clozapine-induced reduction of l-carnitine reabsorption via inhibition/down-regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice.
|
30465787 |
2019 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The introduction of OCT2 into clinical practice may provide significant benefits for imaging peripheral retinal disorders.
|
29160778 |
2019 |
|
Epstein-Barr Virus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
If peripheral T cell lymphoma or T cell lymphomas of follicular helper origin are considered in the differential diagnosis, the following panel is recommended: pan T cell antigens, CD4, CD8, one or more follicular dendritic cell markers, and assessment for Epstein-Barr virus (EBV) infection, preferably EBV encoded RNA (EBER) as assessed by in situ hybridization When the differential diagnosis includes nodular lymphocyte predominant Hodgkin lymphoma, recommended additional studies include OCT2, CD21 and/or CD23, PD1, and assessment for EBV infection.
|
30802809 |
2019 |
|
Chronic pain
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms.
|
30192429 |
2019 |
|
Psychiatric symptom
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
SLC22A2 variants and dolutegravir levels correlate with psychiatric symptoms in persons with HIV.
|
30561642 |
2019 |
|
Psychoticism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Behavioral and psychological symptoms of dementia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The effects of dolutegravir Ctrough and the SLC22A2 gene variant on NPs were explored by multivariable logistic regression.
|
30561642 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Carnitine depletion, characterized by reduced expression of "organic cation transporter-2" gene, is a metabolic and autosomal recessive disorder that also frequently associates with CVD.
|
29241711 |
2018 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Organic cation transporter 2 (OCT2), which is a cisplatin uptake transporter expressed on renal tubules and cochlear hair cells but not on osteosarcoma cells, mediates cisplatin uptake.
|
29445029 |
2018 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest a mechanism whereby circ2174 can act as a sponge to regulate the expression of miR149, and thereby modulate Oct-2 and interleukin-16 signaling pathways in cholangiocarcinoma.
|
30168369 |
2018 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings highlight that OCT2 deficiency was associated with increased lactate levels during metformin treatment caused by CIN.
|
30119251 |
2018 |
|
Osteosarcoma of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Organic cation transporter 2 (OCT2), which is a cisplatin uptake transporter expressed on renal tubules and cochlear hair cells but not on osteosarcoma cells, mediates cisplatin uptake.
|
29445029 |
2018 |
|
Cervical Squamous Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings highlight that OCT2 deficiency was associated with increased lactate levels during metformin treatment caused by CIN.
|
30119251 |
2018 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Organic cation transporter 2 (OCT2), which is a cisplatin uptake transporter expressed on renal tubules and cochlear hair cells but not on osteosarcoma cells, mediates cisplatin uptake.
|
29445029 |
2018 |
|
Contrast - Induced Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
|
30119251 |
2018 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury.
|
28414026 |
2017 |
|
Linear atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cisplatin also reduced the OCT2 intensity in the inner and outer pillar cells and in the stria vascularis as well as the CTR1 intensity in the synapse area around the IHCs, the Deiters' cells, and the stria vascularis.
|
28955207 |
2017 |
|
Mediastinal (Thymic) Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the utility of J chain and myocyte enhancer factor 2B (MEF2B) in the diagnosis of CHL; NLPHL; PMBL; T-cell/histiocyte-rich large B-cell lymphoma (TCRLBL); and B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and CHL, compared with OCT-2 and BOB.1.
|
28851661 |
2017 |
|
T-cell/histiocyte rich large B-cell lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Whereas loss of OCT-2 and/or BOB.1 expression had a sensitivity of only 86% and specificity of 100% for CHL versus NLPHL, PMBL, and TCRLBL, lack of both J chain and MEF2B expression was 100% sensitive and 97% specific.
|
28851661 |
2017 |