|
Multiple Myeloma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, methylation of SPARC and BNIP3 was statistically significantly associated with a poor overall survival of MM patients (P = 0.003 and P = 0.017, respectively).
|
18172295 |
2008 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Under our present experimental conditions, treatment response did not correlate with TP53 or hMLH1 status, but was associated with apoptosis-related genes, most notably BNIP3.Int.J.Cancer (Radiat.Oncol.Invest.)90, 175-185 (2000).
|
10993958 |
2000 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Under our present experimental conditions, treatment response did not correlate with TP53 or hMLH1 status, but was associated with apoptosis-related genes, most notably BNIP3.Int.J.Cancer (Radiat.Oncol.Invest.)90, 175-185 (2000).
|
10993958 |
2000 |
|
Breast Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In addition, we analyzed BNIP3 mutation in the DNA sequences encoding BH3 (Bcl-2 homology3) and TM (transmembrane) domains that are important in the cell death function of BNIP3 by single-strand conformation polymorphism (SSCP) in 48 colorectal, 48 gastric, and 48 breast carcinomas, and 48 acute leukemias.
|
18092960 |
2007 |
|
Liver carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Among these differentially-expressed genes, the galectin-3, serine/threonine kinase SGK, translation factor eIF-4A, -4B, -3, fibroblast growth factor receptor, and ribosomal protein L35A were up-regulated; the mRNAs of Nip3, decorin, and the insulin-like growth factor binding protein-3 were down-regulated in HCC.
|
12521301 |
2002 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, for the first time, we present, by means of a quantitative PCR protocol with reverse transcriptase, the expression of BECN1 and CASP3 genes in the neuronal CA3 region of the hippocampus with the co-expression of the mitochondrial BNIP3 gene, which genes are associated with Alzheimer's disease, in the ischemic model of Alzheimer's disease in the rat.
|
31707369 |
2019 |
|
Brain Ischemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This indicates no involvement of the BNIP3 gene along with the CASP3 gene in the CA3 region of the hippocampus in delayed neuronal death after brain ischemia.
|
31707369 |
2019 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, we analyzed BNIP3 mutation in the DNA sequences encoding BH3 (Bcl-2 homology3) and TM (transmembrane) domains that are important in the cell death function of BNIP3 by single-strand conformation polymorphism (SSCP) in 48 colorectal, 48 gastric, and 48 breast carcinomas, and 48 acute leukemias.
|
18092960 |
2007 |
|
Chronic myeloproliferative disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemical staining was performed on bone marrow trephine biopsies of 81 MPN (with and without JAK2(V617F) and CALR mutations) and 15 normal controls to assess the megakaryocytic expression of biomarkers associated with proliferation (Ki67), apoptosis (Bcl-XL, BNIP-3) and epigenetic regulation (EZH2, SUZ12).
|
26290261 |
2016 |
|
Multiple Myeloma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Interestingly, methylation of SPARC and BNIP3 was statistically significantly associated with a poor overall survival of MM patients (P = 0.003 and P = 0.017, respectively).
|
18172295 |
2008 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
This study investigated the role of BNIP3 in prostate cancer.
|
18163427 |
2008 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
This study investigated the role of BNIP3 in prostate cancer.
|
18163427 |
2008 |
|
Malignant neoplasm of stomach
|
0.310 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
These findings suggest that BNIP3 is directly regulated by hypoxia but that there may be a hormonal independent mechanism coordinating the expression of BNIP3 in prostate tumors.
|
18163427 |
2008 |
|
Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Manganese Poisoning
|
0.300 |
Biomarker
|
disease |
CTD_human |
BNIP3 up-regulation and mitochondrial dysfunction in manganese-induced neurotoxicity.
|
19442826 |
2009 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure.
|
19641503 |
2008 |
|
Heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Congestive heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Congestive heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure.
|
19641503 |
2008 |
|
Chronic Obstructive Airway Disease
|
0.210 |
Biomarker
|
disease |
BEFREE |
Treatment of COPD myotubes with ascorbic acid decreased ROS concentration (p < 0.001), ROS-induced protein carbonylation (p = 0.019), the LC3 2/LC3 1 ratio (p = 0.037), the expression of SQSTM1 (p < 0.001) and BNIP3 (p < 0.001), and increased the COPD myotube diameter (p < 0.001).
|
29943813 |
2018 |
|
Myocardial Infarction
|
0.210 |
Biomarker
|
disease |
BEFREE |
Thus, the purpose of this study was to test the hypothesis that miR-105 participates in the regulation of RIP3/p-MLKL- and BNIP3-dependent necroptosis/apoptosis in H9c2 cells and MI rat hearts.
|
30743213 |
2019 |
|
Myocardial Infarction
|
0.210 |
Biomarker
|
disease |
RGD |
The key findings of the present study were: a) upregulation of autophagy-related genes (GABARAPL1, ATG7, BNIP3, CTSL1 and LAMP2) was observed only in plantaris while muscle atrophy was observed in both soleus and plantaris muscles, and b) Cathepsin L activity, Bnip3 and Fis1 protein levels, and levels of lipid hydroperoxides were increased specifically in plantaris muscle of MI rats.
|
24427319 |
2014 |
|
Retinal Detachment
|
0.210 |
Biomarker
|
disease |
BEFREE |
Our previous study demonstrated the protective effect on detached retina by BNIP3-mediated autophagy.
|
31072291 |
2019 |