|
Multiple Myeloma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Serum deprivation markedly blocked survival at earlier time points in CS1 knockdown compared with control MM cells, associated with earlier activation of caspases, poly(ADP-ribose) polymerase, and proapoptotic proteins BNIP3 and BIK.
|
19196658 |
2009 |
|
Multiple Myeloma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Interestingly, methylation of SPARC and BNIP3 was statistically significantly associated with a poor overall survival of MM patients (P = 0.003 and P = 0.017, respectively).
|
18172295 |
2008 |
|
Multiple Myeloma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, methylation of SPARC and BNIP3 was statistically significantly associated with a poor overall survival of MM patients (P = 0.003 and P = 0.017, respectively).
|
18172295 |
2008 |
|
Multiple Myeloma
|
0.330 |
PosttranslationalModification
|
disease |
BEFREE |
Among primary tumours, methylation of BNIP3 was detected in five of 34 (15%) acute lymphocytic leukaemias, six of 35 (17%) acute myelogenous leukaemias and three of 14 (21%) multiple myelomas.
|
15756280 |
2005 |
|
Malignant neoplasm of prostate
|
0.320 |
PosttranslationalModification
|
disease |
BEFREE |
Hypomethylation of BNIP3 (31.25 ± 16.19 vs. 45.70 ± 2.42 %, p < 0.0001), hypermethylation of Ec-SOD (71.4 ± 6.75 vs. 10.0 ± 3.78 %, p < 0.0001) and RASSF1 (76.25 ± 12.53 vs. 30.0 ± 8.82 %, p = 0.0077) was observed in prostate cancer.
|
23979608 |
2013 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
This study investigated the role of BNIP3 in prostate cancer.
|
18163427 |
2008 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
This study investigated the role of BNIP3 in prostate cancer.
|
18163427 |
2008 |
|
Prostatic Neoplasms
|
0.310 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that BNIP3 is directly regulated by hypoxia but that there may be a hormonal independent mechanism coordinating the expression of BNIP3 in prostate tumors.
|
18163427 |
2008 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
These findings suggest that BNIP3 is directly regulated by hypoxia but that there may be a hormonal independent mechanism coordinating the expression of BNIP3 in prostate tumors.
|
18163427 |
2008 |
|
Malignant neoplasm of stomach
|
0.310 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Malignant neoplasm of stomach
|
0.310 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant methylation of BNIP3 was also detected in 66% of primary colorectal and 49% of primary gastric cancers, but not in normal tissue samples collected from areas adjacent to the tumors.
|
15709167 |
2005 |
|
Manganese Poisoning
|
0.300 |
Biomarker
|
disease |
CTD_human |
BNIP3 up-regulation and mitochondrial dysfunction in manganese-induced neurotoxicity.
|
19442826 |
2009 |
|
Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Congestive heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Heart failure
|
0.230 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we reviewed the changes in BNIP3 protein expression levels during inflammatory response and postulated its role in inflammation-mediated HF.
|
27112557 |
2016 |
|
Congestive heart failure
|
0.230 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we reviewed the changes in BNIP3 protein expression levels during inflammatory response and postulated its role in inflammation-mediated HF.
|
27112557 |
2016 |
|
Heart failure
|
0.230 |
Therapeutic
|
disease |
RGD |
In systolic HF, the downregulation of SERCA2a (sarcoplasmic-endoplasmic reticulum calcium ATPase), along with an increased BNIP3 expression, further worsen myocardial diastolic and systolic function and contribute to the major remodeling seen in systolic HF as compared with diastolic HF with normal SERCA2a expression.
|
23508759 |
2013 |
|
Congestive heart failure
|
0.230 |
Therapeutic
|
disease |
RGD |
In systolic HF, the downregulation of SERCA2a (sarcoplasmic-endoplasmic reticulum calcium ATPase), along with an increased BNIP3 expression, further worsen myocardial diastolic and systolic function and contribute to the major remodeling seen in systolic HF as compared with diastolic HF with normal SERCA2a expression.
|
23508759 |
2013 |
|
Heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure.
|
19641503 |
2008 |
|
Congestive heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure.
|
19641503 |
2008 |
|
Myocardial Infarction
|
0.210 |
Biomarker
|
disease |
BEFREE |
Thus, the purpose of this study was to test the hypothesis that miR-105 participates in the regulation of RIP3/p-MLKL- and BNIP3-dependent necroptosis/apoptosis in H9c2 cells and MI rat hearts.
|
30743213 |
2019 |
|
Retinal Detachment
|
0.210 |
Biomarker
|
disease |
BEFREE |
Our previous study demonstrated the protective effect on detached retina by BNIP3-mediated autophagy.
|
31072291 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.210 |
Biomarker
|
disease |
BEFREE |
Treatment of COPD myotubes with ascorbic acid decreased ROS concentration (p < 0.001), ROS-induced protein carbonylation (p = 0.019), the LC3 2/LC3 1 ratio (p = 0.037), the expression of SQSTM1 (p < 0.001) and BNIP3 (p < 0.001), and increased the COPD myotube diameter (p < 0.001).
|
29943813 |
2018 |